Sanders Matthew J, Wiltgen Brian J, Fanselow Michael S
UCLA Psychology Department, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095-1563, USA.
Eur J Pharmacol. 2003 Feb 28;463(1-3):217-23. doi: 10.1016/s0014-2999(03)01283-4.
Pavlovian fear conditioning is a phenomenon amenable to laboratory analysis of the neurobiology of fear and the investigation of neural mechanisms of learning and memory. Investigators have made much progress in delineating the neurocircuitry and neurochemistry of fear conditioning. The place of the hippocampus in context fear remains a controversial issue. In this review, we examine the evidence that the hippocampus plays a role in fear conditioning. We then critically examine hypotheses concerning its exact role in learning and memory for cued and context fear conditioning.
巴甫洛夫恐惧条件反射是一种适合在实验室中对恐惧神经生物学进行分析以及对学习和记忆神经机制进行研究的现象。研究人员在描绘恐惧条件反射的神经回路和神经化学方面取得了很大进展。海马体在情境恐惧中的作用仍然是一个有争议的问题。在这篇综述中，我们研究了海马体在恐惧条件反射中发挥作用的证据。然后，我们批判性地审视了关于其在线索性和情境性恐惧条件反射的学习和记忆中的确切作用的假说。
