Brissot P, Campion J P, Guillouzo A, Allain H, Messner M, Simon M, Ferrand B, Bourel M
Dig Dis Sci. 1983 Jul;28(7):616-24. doi: 10.1007/BF01299922.
Four baboons receiving intramuscular iron for 15 months were compared with two control baboons. From the overall two-year observation period the following data emerge: (1) The baboon is a suitable animal for obtaining a massive and chronic iron overload. Liver iron concentrations reached very high levels (ranging from 41.3 to 180.6 mumol/100 mg dry weight vs 1.7 +/- 0.5, mean +/- SEM, in controls), and a major liver iron overload (ie, with concentration values greater than or equal to 18) was present in all four animals for an average period of 16.5 months (range 14-19). (2) When compared with human hepatic iron-overload disorders, iron distribution was similar to that observed in secondary (transfusional) hepatic siderosis since iron deposits were found primarily in sinusoidal cells. However, a marked parenchymal siderosis was also obtained close to that observed in primary (genetic) siderosis. Iron toxicity was present biologically as indicated by an increase in serum transaminases. Histologically, a slight fibrosis was observed in the most heavily iron-overloaded baboon. On the whole, this study of subhuman primates brings new evidence that iron per se has only a minor hepatic damaging effect. It also suggests that the iron-overloaded baboon liver provides a promising tool for the study of liver cell disturbances in human iron overload.
将接受肌肉注射铁剂15个月的4只狒狒与2只对照狒狒进行了比较。从整个两年的观察期得出以下数据：(1)狒狒是获得大量慢性铁过载的合适动物。肝脏铁浓度达到非常高的水平（范围为41.3至180.6 μmol/100 mg干重，而对照组为1.7±0.5，均值±标准误），并且所有4只动物均出现主要肝脏铁过载（即浓度值大于或等于18），平均持续时间为16.5个月（范围14 - 19个月）。(2)与人类肝脏铁过载疾病相比，铁分布与继发性（输血性）肝铁质沉着症中观察到的相似，因为铁沉积主要在窦状细胞中发现。然而，也获得了与原发性（遗传性）铁质沉着症中观察到的相近的明显实质铁质沉着症。血清转氨酶升高表明存在铁毒性。组织学上，在铁过载最严重的狒狒中观察到轻微纤维化。总体而言，这项对非人灵长类动物的研究提供了新的证据，即铁本身仅具有轻微的肝脏损伤作用。它还表明，铁过载的狒狒肝脏为研究人类铁过载中的肝细胞紊乱提供了一个有前景的工具。
