Hidaka Saburo, Okamoto Yoshizo, Miyazaki Koji, Uesugi Takehiko
Department of Dental Hygiene, Fukuoka College of Health Sciences, Fukuoka, Japan.
Phytother Res. 2003 Feb;17(2):112-9. doi: 10.1002/ptr.1047.
The preventive effects of Fujiflavone P40 (a soybean isoflavone product) against both bone loss and periodontal alteration were evaluated using an ovariectomized rat model. Rats were divided into five groups: sham-operated (Sham), ovariectomized (OVX), OVX given Fujiflavone P40, OVX given 17beta-oestradiol, and OVX given the vehicle for 17beta-oestradiol, respectively. Fujiflavone P40 contains 46.6% isoflavones which consist of 24.1% daidzin, 16.5% glycitin and 5.9% genistin. Administration of Fujiflavone P40 to OVX rats suppressed the body weight gain until 5 weeks. Fujiflavone P40 also decreased total and high-density lipoprotein (HDL) cholesterols and triglyceride level of OVX rats, significantly. After 7 weeks, Fujiflavone P40 did not recover the coarsened fibre of the periodontal ligament. The ovariectomy decreased the uterine weight by 78%. The administration of 17beta -oestradiol recovered the weight loss by 99%, while Fujiflavone P40 restored it by 33%. The ovariectomy decreased the tibial bone mineral density (BMD) by 22%. The administration of 17beta-oestradiol to OVX rats recovered the tibial BMD decrease by 100%, while Fujiflavone P40 recovered it by 78%. The results suggest that Fujiflavone P40 may be useful as a preventive agent for osteoporosis.
使用去卵巢大鼠模型评估了藤黄酮P40（一种大豆异黄酮产品）对骨质流失和牙周改变的预防作用。大鼠被分为五组：假手术组（Sham）、去卵巢组（OVX）、给予藤黄酮P40的去卵巢组、给予17β-雌二醇的去卵巢组以及给予17β-雌二醇溶剂的去卵巢组。藤黄酮P40含有46.6%的异黄酮，其中包括24.1%的大豆苷、16.5%的染料木苷和5.9%的染料木素。给去卵巢大鼠服用藤黄酮P40可抑制其体重增加直至5周。藤黄酮P40还显著降低了去卵巢大鼠的总胆固醇、高密度脂蛋白（HDL）胆固醇和甘油三酯水平。7周后，藤黄酮P40未能恢复牙周韧带变粗的纤维。去卵巢使子宫重量减少了78%。给予17β-雌二醇可使体重减轻恢复99%，而藤黄酮P40可使其恢复33%。去卵巢使胫骨骨矿物质密度（BMD）降低了22%。给去卵巢大鼠服用17β-雌二醇可使胫骨BMD降低恢复100%，而藤黄酮P40可使其恢复了78%。结果表明，藤黄酮P40可能作为骨质疏松症的预防剂有用。
