苯二氮䓬类药物与中枢甘氨酸受体。
Benzodiazepines and central glycine receptors.
作者信息
Curtis D R, Game C J, Lodge D
出版信息
Br J Pharmacol. 1976 Mar;56(3):307-11. doi: 10.1111/j.1476-5381.1976.tb07643.x.
Abstract
1 In cats, anaesthetized with pentobarbitone, intravenous diazepam (minimum dose 3.0 mg/kg) enhanced dorsal root potentials but did not significantly diminish the reduction by electrophoretic strychnine of the inhibitory action of electrophoretic glycine on dorsal horn interneurones. 2 In mice, intraperitoneal diazepam (2.5 mg/kg) had no appreciable effect on the potency of strychnine as a convulsant, although providing some protection against bicuculline. 3 These observations, together with the failure of chlordiazepoxide to either inhibit the firing of spinal interneurones or reduce antagonism between strychnine and glycine when administered locally, provide no support for the interaction between benzodiazepines and mammalian central glycine receptors which has been proposed on the basis of in vitro studies of strychnine binding.
摘要
- 在用戊巴比妥麻醉的猫中，静脉注射地西泮（最小剂量3.0毫克/千克）可增强背根电位，但并未显著减弱电泳注射士的宁对电泳注射甘氨酸对背角中间神经元抑制作用的减弱效果。2. 在小鼠中，腹腔注射地西泮（2.5毫克/千克）对士的宁作为惊厥剂的效力没有明显影响，尽管对荷包牡丹碱有一定的保护作用。3. 这些观察结果，以及当局部给药时氯氮卓未能抑制脊髓中间神经元的放电或减少士的宁与甘氨酸之间的拮抗作用，不支持基于士的宁结合的体外研究提出的苯二氮卓类与哺乳动物中枢甘氨酸受体之间的相互作用。
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