Kormosh N, Laktionov K, Antoshechkina M
NN Blokhin Cancer Research Center of Russian Academy of Medical Sciences, Moscow, Russian Federation.
Phytother Res. 2006 May;20(5):424-5. doi: 10.1002/ptr.1889.
The influence of a plant preparation AdMax (Nulab Inc., Clearwater, FL, USA) on immunity in ovarian cancer patients was studied. The preparation is a combination of dried ethanol/water extracts from roots of Leuzea carthamoides, Rhodiola rosea, Eleutherococcus senticosus and fruits of Schizandra chinensis. Twenty eight patients with stage III-IV epithelial ovarian cancer were treated once with 75 mg/m(2) cisplatin and 600 mg/m(2) cyclophosphamide. Peripheral blood was collected 4 weeks after the chemotherapy. Subclasses of T, B and NK lymphocytes were tested for in the blood samples: CD3, CD4, CD5, CD7, CD8, CD11B, CD16, CD20, CD25, CD38, CD45RA, CD50, CD71 and CD95. Immunoglobulin G, A and M concentrations were also determined. Changes were observed in the following T cell subclasses: CD3, CD4, CD5 and CD8. In patients who took AdMax (270 mg a day) for 4 weeks following the chemotherapy, the mean numbers of the four T cell subclasses were increased in comparison with the mean numbers of the T cell subclasses in patients who did not take AdMax. In patients who took AdMax, the mean amounts of IgG and IgM were also increased. The obtained results suggest that the combination of extracts from adaptogenic plants may boost the suppressed immunity in ovarian cancer patients who are subject to chemotherapy.
研究了一种植物制剂AdMax（美国佛罗里达州克利尔沃特市Nulab公司）对卵巢癌患者免疫力的影响。该制剂是由光果列当、红景天、刺五加的根以及五味子果实的乙醇/水干燥提取物混合而成。28例III-IV期上皮性卵巢癌患者接受了一次75mg/m²顺铂和600mg/m²环磷酰胺的治疗。化疗4周后采集外周血。检测血样中的T、B和NK淋巴细胞亚群：CD3、CD4、CD5、CD7、CD8、CD11B、CD16、CD20、CD25、CD38、CD45RA、CD50、CD71和CD95。还测定了免疫球蛋白G、A和M的浓度。观察到以下T细胞亚群发生了变化：CD3、CD4、CD5和CD8。在化疗后服用AdMax（每天270mg）4周的患者中，这四个T细胞亚群的平均数量相较于未服用AdMax的患者T细胞亚群平均数量有所增加。在服用AdMax的患者中，IgG和IgM的平均含量也有所增加。所得结果表明，适应原植物提取物的组合可能会增强接受化疗的卵巢癌患者受到抑制的免疫力。
