红霉素与青霉素或头孢噻肟联合应用对肺炎链球菌体外缺乏协同作用。
Lack of synergy of erythromycin combined with penicillin or cefotaxime against Streptococcus pneumoniae in vitro.
作者信息
Lin Eugene, Stanek Ronald J, Mufson Maurice A
机构信息
Department of Medicine, Marshall University School of Medicine, Huntington, West Virginia 25701-3655, USA.
出版信息
Antimicrob Agents Chemother. 2003 Mar;47(3):1151-3. doi: 10.1128/AAC.47.3.1151-1153.2003.
Abstract
We investigated a possible synergistic effect of a macrolide and beta-lactams against Streptococcus pneumoniae strains with different resistance profiles. Checkerboard and time-kill assays of erythromycin combined with penicillin or cefotaxime essentially showed indifference, suggesting that these antibiotics in combinations in vitro act substantially as individuals in their activity against S. pneumoniae.
摘要
我们研究了大环内酯类药物与β-内酰胺类药物对不同耐药谱的肺炎链球菌菌株可能存在的协同作用。红霉素与青霉素或头孢噻肟的棋盘法和杀菌动力学试验结果基本显示无协同作用，这表明这些抗生素联合使用时，在体外对肺炎链球菌的活性基本上与单独使用时相同。
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