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2
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本文引用的文献

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Testing of Streptococcus pneumoniae for resistance to penicillin.肺炎链球菌对青霉素耐药性的检测。
J Clin Microbiol. 1993 May;31(5):1246-50. doi: 10.1128/jcm.31.5.1246-1250.1993.
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Dilemmas in diagnosis and management of cephalosporin-resistant Streptococcus pneumoniae meningitis.耐头孢菌素肺炎链球菌脑膜炎的诊断与管理困境
Pediatr Infect Dis J. 1993 Mar;12(3):196-200. doi: 10.1097/00006454-199303000-00004.
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The in-vitro activity of combinations of penicillin and gentamicin against penicillin-resistant and penicillin-sensitive Streptococcus pneumoniae.青霉素与庆大霉素联合用药对耐青霉素和对青霉素敏感的肺炎链球菌的体外活性。
J Antimicrob Chemother. 1986 Sep;18(3):426-8. doi: 10.1093/jac/18.3.426.
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Interaction between beta-lactam antibiotics and gentamicin against Streptococcus pneumoniae in vitro and in vivo.β-内酰胺类抗生素与庆大霉素对肺炎链球菌的体外及体内相互作用。
Acta Pathol Microbiol Immunol Scand B. 1987 Oct;95(5):269-75. doi: 10.1111/j.1699-0463.1987.tb03124.x.
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Characteristics and antibiotic therapy of adult meningitis due to penicillin-resistant pneumococci.耐青霉素肺炎球菌所致成人脑膜炎的特征及抗生素治疗
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Multicenter evaluation of the use of Haemophilus test medium for broth microdilution antimicrobial susceptibility testing of Streptococcus pneumoniae and development of quality control limits.嗜血杆菌测试培养基用于肺炎链球菌肉汤微量稀释法抗菌药物敏感性试验的多中心评估及质量控制限度的制定。
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In vivo antibiotic synergism: contribution of animal models.体内抗生素协同作用：动物模型的贡献
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Aminoglycoside therapy of gram-negative bacillary meningitis.革兰氏阴性杆菌性脑膜炎的氨基糖苷类药物治疗
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β-内酰胺类抗生素和庆大霉素对青霉素敏感和耐药肺炎球菌的抗菌活性。

Antimicrobial activities of beta-lactam antibiotics and gentamicin against penicillin-susceptible and penicillin-resistant pneumococci.

作者信息

Gross M E, Giron K P, Septimus J D, Mason E O, Musher D M

机构信息

Medical Service, Veterans Affairs Medical Center, Houston, TX 77030, USA.

出版信息

Antimicrob Agents Chemother. 1995 May;39(5):1166-8. doi: 10.1128/AAC.39.5.1166.

DOI:10.1128/AAC.39.5.1166
PMID:7625807
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC162702/
Abstract

The MICs of penicillin and cefotaxime for a range of penicillin-susceptible and penicillin-resistant isolates of Streptococcus pneumoniae were unchanged by the addition of gentamicin. In time-kill studies the rate of killing was greater for 18 of 20 isolates in the presence of gentamicin. However, mean differences in killing after 6 h of incubation were modest, not exceeding 1 log10 unit.

摘要

对于一系列对青霉素敏感和耐药的肺炎链球菌分离株，加入庆大霉素后青霉素和头孢噻肟的最低抑菌浓度（MIC）没有变化。在时间-杀菌研究中，20株分离株中有18株在庆大霉素存在时的杀菌速率更高。然而，孵育6小时后的平均杀菌差异不大，不超过1个对数10单位。