Arnett Peter A, Higginson Christopher I, Voss William D, Randolph John J, Grandey Alicia A
Penn State University, Psychology Department, University Park, PA 16802-3105, USA.
Clin Neuropsychol. 2002 Aug;16(3):341-55. doi: 10.1076/clin.16.3.341.13852.
Given its relatively high prevalence, one possible source of stress for patients with multiple sclerosis (MS) is cognitive dysfunction. The authors' study was guided by a new theoretical model suggesting that cognitive dysfunction in MS may be most likely to lead to depression when patients use high levels of avoidance coping and/or low levels of active coping. To test this model, 55 patients with definite MS were administered a neuropsychological battery and measures of depression and coping. Consistent with predictions, regression analyses showed that coping significantly moderated the relationship between cognitive dysfunction and depression. Specifically, cognitive dysfunction was most likely to be associated with depression when patients used either high levels of avoidance or low levels of active coping. Implications of these data for clinical applications and for our theoretical conceptualization are discussed and limitations of the model explored.
鉴于其相对较高的患病率，多发性硬化症（MS）患者面临的一个可能的压力源是认知功能障碍。作者的研究以一种新的理论模型为指导，该模型表明，当MS患者采用高水平的回避应对方式和/或低水平的积极应对方式时，认知功能障碍最有可能导致抑郁。为了验证该模型，对55名确诊为MS的患者进行了神经心理测验以及抑郁和应对方式的测量。与预测一致，回归分析表明，应对方式显著调节了认知功能障碍与抑郁之间的关系。具体而言，当患者采用高水平的回避应对方式或低水平的积极应对方式时，认知功能障碍最有可能与抑郁相关。本文讨论了这些数据对临床应用和理论概念化的意义，并探讨了该模型的局限性。
