Husain Khairana, Jantan Ibrahim, Said Ikram M, Aimi Norio, Takayama Hiromitsu
Department of Pharmacy, Faculty of Allied Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.
J Asian Nat Prod Res. 2003 Mar;5(1):63-7. doi: 10.1080/1028602031000080487.
Two new indole alkaloids with the methyl chanofruticosinate skeletal system viz., methyl 3-oxo-12-methoxy-N1-decarbomethoxy-14,15-didehydrochanofruticosinate (1) and methyl 3-oxo-11,12-methylenedioxy-N-decarbomethoxy-14,15-didehydrochanofruticosinate (2), together with four known compounds, methyl 12-methoxy-N1-decarbomethoxychanofruticosinate, methyl 12-methoxychanofruticosinate, methyl 11,12-dimethoxychanofruticosinate and methyl 11,12-methylenedioxy-N1-decarbomethoxychanofruticosinate, were isolated in continuing studies on the leaves of Kopsia flavida Blume. The structures of the new indole alkaloids were assigned by NMR spectral data using various 2D-techniques.
对黄花蕊木（Kopsia flavida Blume）叶片的持续研究中，分离得到了两种具有甲基长春弗鲁蒂辛骨架系统的新吲哚生物碱，即3-氧代-12-甲氧基-N1-脱甲氧基-14,15-二脱氢长春弗鲁蒂辛甲酯（1）和3-氧代-11,12-亚甲基二氧基-N-脱甲氧基-14,15-二脱氢长春弗鲁蒂辛甲酯（2），以及四种已知化合物，12-甲氧基-N1-脱甲氧基长春弗鲁蒂辛甲酯、12-甲氧基长春弗鲁蒂辛甲酯、11,12-二甲氧基长春弗鲁蒂辛甲酯和11,12-亚甲基二氧基-N1-脱甲氧基长春弗鲁蒂辛甲酯。通过使用各种二维技术的核磁共振光谱数据确定了新吲哚生物碱的结构。
