Zitzmann N U, Schärer P, Marinello C P, Schüpbach P, Berglundh T
Clinic of Fixed and Removable Prosthodontics and TMJ Disorders, University of Basel, Switzerland.
Int J Periodontics Restorative Dent. 2001 Jun;21(3):288-95.
The aim of the present study was to investigate the healing of alveolar ridge defects augmented with cancellous bovine bone mineral. In six partially edentulous patients, bone augmentation was necessary prior to implant placement because of severe alveolar ridge resorption. The defect sites, all located in the maxilla, were filled with Bio-Oss and covered with the resorbable collagen membrane Bio-Gide. Biopsies were obtained from the defect sites 6 to 7 months following grafting and were processed for ground sectioning. The histologic analysis revealed that the Bio-Oss particles occupied 31% of the total biopsy area. An intimate contact between woven bone and Bio-Oss was detected along 37% of the particle surfaces. A mixed type of bone was found; it contained woven bone and parallel-fibered bone, which demonstrates features of remodeling activity. Signs of resorption of the grafting material were observed in the histologic sections, which indicates that the material takes part in the remodeling process. It is suggested that Bio-Oss may be a very suitable material for staged localized ridge augmentation in humans.
本研究的目的是调查用松质牛骨矿物质增强牙槽嵴缺损的愈合情况。在6名部分牙列缺失患者中，由于严重的牙槽嵴吸收，在种植体植入前需要进行骨增量。所有缺损部位均位于上颌，用Bio-Oss填充并用可吸收胶原膜Bio-Gide覆盖。在移植后6至7个月从缺损部位获取活检组织，并进行磨片处理。组织学分析显示，Bio-Oss颗粒占活检总面积的31%。沿37%的颗粒表面检测到编织骨与Bio-Oss之间存在紧密接触。发现了一种混合型骨；它包含编织骨和平行纤维骨，这表明具有重塑活动的特征。在组织学切片中观察到移植材料的吸收迹象，这表明该材料参与了重塑过程。提示Bio-Oss可能是人类分期局部牙槽嵴增量的非常合适的材料。
