来自冲绳海洋海绵Ircinia sp.的新型细胞毒性呋喃酯萜类化合物

New cytotoxic furanosesterterpenes from an Okinawan marine sponge, Ircinia sp.

作者信息

Issa Hamad H, Tanaka Junichi, Higa Tatsuo

机构信息

Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan.

出版信息

J Nat Prod. 2003 Feb;66(2):251-4. doi: 10.1021/np020456p.

DOI:10.1021/np020456p

PMID:12608859

Abstract

Five new sesterterpenes have been isolated from a lipophilic extract of a sponge, Ircinia sp., and their structures elucidated by spectroscopic and chemical methods. The absolute configurations of two metabolites (1, 3) were established by chemical degradation. These compounds showed moderate cytotoxicity against KB cells.

摘要

从一种海绵Ircinia sp.的亲脂性提取物中分离出了五种新的倍半萜，并通过光谱和化学方法阐明了它们的结构。通过化学降解确定了两种代谢产物（1, 3）的绝对构型。这些化合物对KB细胞显示出中等程度的细胞毒性。