来自海绵Smenospongia sp.的新型倍半萜烯

New sesterterpenes from the sponge Smenospongia sp.

作者信息

Rho Jung-Rae, Lee Hyi-Seung, Shin Hee Jae, Ahn Jong-Woong, Kim Ji-Yun, Sim Chung J, Shin Jongheon

机构信息

Marine Natural Products Laboratory, Korea Ocean Research & Development Institute, Ansan PO Box 29, Seoul 425-600.

出版信息

J Nat Prod. 2004 Oct;67(10):1748-51. doi: 10.1021/np040103l.

DOI:10.1021/np040103l

PMID:15497955

Abstract

Five new sesterterpenes, three scalarane-type (1-3) and two linear furanosesterterpenes (4, 5), were isolated from the marine sponge Smenospongia sp. collected from Gagu-Do, Korea. The structures of the new compounds, which exhibited moderate cytotoxicity toward the human leukemia cell line K562, were determined from an analysis of spectroscopic data.

摘要

从韩国加古岛采集的海绵动物斯氏海绵（Smenospongia sp.）中分离出了5种新的倍半萜，其中3种为四环三萜型（1-3），2种为线性呋喃倍半萜（4, 5）。通过光谱数据分析确定了这些对人白血病细胞系K562表现出中等细胞毒性的新化合物的结构。