Wonganuchitmeta Saeng-ngam, Yuenyongsawad Supreeya, Keawpradub Niwat, Plubrukarn Anuchit
Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand.
J Nat Prod. 2004 Oct;67(10):1767-70. doi: 10.1021/np0498354.
A new scalarane-type sesterterpene, 12-deacetoxyscalarin 19-acetate (2), and two naturally new derivatives of manoalide-type sesterterpenes, (E)- and (Z)-neomanoalide 24,25-diacetates (3 and 4), were isolated from the Thai sponge Brachiaster sp., along with five other known sesterterpenes: heteronemin (1), heteronemin acetate (5), 12-epi-19-deoxyscalarin (6), 12-deacetyl-12-epi-19-deoxyscalarin (7), and manoalide 25-acetate (8). The antitubercular and cytotoxic activities of all eight compounds were evaluated to reveal the potent activity of compounds 1, 2, 5, and 8. Among these, compound 2 showed an interesting bioactivity profile, in possessing potent antitubercular activity and being practically inactive in the cytotoxicity bioassay.
从泰国海绵 Brachiaster sp. 中分离出一种新的四环三萜型倍半萜，12-脱乙酰基卡拉林 19-乙酸酯（2），以及两种新的马诺内酯型倍半萜天然衍生物，（E）-和（Z）-新马诺内酯 24,25-二乙酸酯（3 和 4），同时还分离出其他五种已知的倍半萜：异壬二烯（1）、异壬二烯乙酸酯（5）、12-表-19-脱氧卡拉林（6）、12-脱乙酰基-12-表-19-脱氧卡拉林（7）和马诺内酯 25-乙酸酯（8）。对所有八种化合物的抗结核和细胞毒性活性进行了评估，结果显示化合物 1、2、5 和 8 具有较强的活性。其中，化合物 2 表现出有趣的生物活性特征，具有较强的抗结核活性，而在细胞毒性生物测定中几乎没有活性。
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