Department of Pharmaceutical Biology, Pharmaceutical Institute, University of Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany.
Department of Microbial Bioactive Compounds, Interfaculty Institute of Microbiology and Infection Medicine (IMIT), University of Tübingen, Auf der Morgenstelle 28, 72076 Tübingen, Germany.
Mar Drugs. 2022 Aug 19;20(8):532. doi: 10.3390/md20080532.
Two new ircinianin-type sesterterpenoids, ircinianin lactone B and ircinianin lactone C ( and ), together with five known entities from the ircinianin compound family (, -) were isolated from the marine sponge . Ircinianin lactones B and C ( and ) represent new ircinianin terpenoids with a modified oxidation pattern. Despite their labile nature, the structures could be established using a combination of spectroscopic data, including HRESIMS and 1D/2D NMR techniques, as well as computational chemistry and quantum-mechanical calculations. In a broad screening approach for biological activity, the class-defining compound ircinianin () showed moderate antiprotozoal activity against (IC 25.4 μM) and (IC 16.6 μM).
从海洋海绵中分离得到两种新的伊辛烷型倍半萜内酯，伊辛烷内酯 B 和伊辛烷内酯 C（和），以及伊辛烷化合物家族的五种已知实体（，-）。伊辛烷内酯 B 和 C（和）代表具有修饰的氧化模式的新型伊辛烷萜类化合物。尽管它们的性质不稳定，但可以使用包括 HRESIMS 和 1D/2D NMR 技术以及计算化学和量子力学计算在内的光谱数据组合来建立结构。在广泛的生物活性筛选方法中，该类定义化合物伊辛烷（）对（IC 25.4 μM）和（IC 16.6 μM）表现出中等的抗原生动物活性。
