S(R)-坡豆内酯D，一种从罗汉松变种小叶罗汉松中分离得到的含亚砜基的新二萜双内酯。

S(R)-podolactone D, a new sulfoxide-containing norditerpene dilactone from Podocarpus macrophyllus var. maki.

作者信息

Park Hyun-Sun, Takahashi Yoshinao, Fukaya Haruhiko, Aoyagi Yutaka, Takeya Koichi

机构信息

School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.

出版信息

J Nat Prod. 2003 Feb;66(2):282-4. doi: 10.1021/np020334x.

DOI:10.1021/np020334x

PMID:12608867

Abstract

S(R)()-Podolactone D (1), a new norditerpene dilactone having a methylsulfoxide moiety, was isolated from the leaves of Podocarpus macrophyllus D. Don var. maki Endl. along with known podolactone D (2, S(S)()-podolactone D). The structures and absolute configurations of compounds 1 and 2 were elucidated by spectral methods (HREIMS, IR, (1)H, (13)C, and 2D NMR) and finally confirmed by single-crystal X-ray analyses. The cytotoxic effects of compounds 1 and 2 on P388 murine leukemia cells were also examined.

摘要

从罗汉松（Podocarpus macrophyllus D. Don var. maki Endl.）的叶子中分离出一种新的具有甲亚砜部分的降二萜双内酯S(R)()-罗汉松内酯D（1），以及已知的罗汉松内酯D（2，S(S)()-罗汉松内酯D）。通过光谱方法（高分辨电子轰击质谱、红外光谱、氢谱、碳谱和二维核磁共振谱）阐明了化合物1和2的结构及绝对构型，最终通过单晶X射线分析得以确证。还检测了化合物1和2对P388小鼠白血病细胞的细胞毒性作用。