Utsumi Nanae, Hayasaka Tadashi, Motoyama Teiichi
Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan.
Pathol Int. 2003 Mar;53(3):191-4. doi: 10.1046/j.1440-1827.2003.01454.x.
A case of a 58-year-old woman with ovarian carcinoid exhibiting double function is reported. She had suffered from constipation and hirsutism before surgery. Pathological examination revealed that many carcinoid tumor cells were immunohistochemically positive for peptide YY, which inhibits intestinal motility and many peripheral steroid cells. After surgery the patient recovered from constipation immediately. Although the serum level of testosterone also immediately decreased, hirsutism remained for about 2 years. These clinical manifestations are considered to be due to peptide hormone-producing tumor parenchymal cells and testosterone-producing functioning stromal cells. This is the first report of clinically manifested double-functioning ovarian carcinoid; one function is due to tumor cells themselves and another function is due to stromal cells.
报告了一例58岁具有双重功能的卵巢类癌患者。术前她患有便秘和多毛症。病理检查显示，许多类癌肿瘤细胞免疫组化检测肽YY呈阳性，肽YY可抑制肠道蠕动和许多外周类固醇细胞。术后患者便秘立即缓解。虽然睾酮血清水平也立即下降，但多毛症持续了约2年。这些临床表现被认为是由于产生肽激素的肿瘤实质细胞和产生睾酮的功能性基质细胞所致。这是首例具有临床表现的双重功能卵巢类癌的报告；一种功能归因于肿瘤细胞本身，另一种功能归因于基质细胞。
