Mitchell Robert, Rochtchina Elena, Lee Anne, Wang Jie Jin, Mitchell Paul
Christchurch School of Medicine, University of Otago, Christchurch, New Zealand.
Am J Ophthalmol. 2003 Mar;135(3):384-6. doi: 10.1016/s0002-9394(02)01967-0.
To assess the relationship between iris color and intraocular pressure (IOP).
Population-based, cross-sectional study.
The Blue Mountains Eye Study examined 3,654 largely Caucasian participants, aged 49 to 97 years, from 1992 to 1994. Information was collected about glaucoma risk factors, and Goldmann applanation IOP measurements were taken. Iris color was assessed by comparing the undilated appearance of each eye with three standard photographs. Participants who had previous cataract or glaucoma surgery and those using glaucoma medications were excluded.
Mean IOP measurements increased with increasing grades of iris pigmentation. After simultaneous adjustment for variables associated with IOP, mean measurements were 15.92 mm Hg for blue iris color, 16.04 mm Hg for hazel or green, 16.11 mm Hg for tan-brown, and 16.49 mm Hg for dark brown (P for trend = .001).
This study demonstrates a modest but statistically significant association between increasing iris color and IOP.
评估虹膜颜色与眼压（IOP）之间的关系。
基于人群的横断面研究。
蓝山眼研究在1992年至1994年期间对3654名主要为白种人、年龄在49至97岁的参与者进行了检查。收集了有关青光眼危险因素的信息，并采用Goldmann压平眼压测量法进行眼压测量。通过将每只眼睛未散瞳时的外观与三张标准照片进行比较来评估虹膜颜色。排除曾接受白内障或青光眼手术的参与者以及正在使用青光眼药物的参与者。
平均眼压测量值随着虹膜色素沉着程度的增加而升高。在同时对与眼压相关的变量进行调整后，蓝色虹膜颜色的平均测量值为15.92毫米汞柱，淡褐色或绿色为16.04毫米汞柱，棕褐色为16.11毫米汞柱，深褐色为16.49毫米汞柱（趋势P值 = 0.001）。
本研究表明虹膜颜色加深与眼压之间存在适度但具有统计学意义的关联。
