Rochtchina Elena, Mitchell Paul, Wang Jie Jin
Department of Ophthalmology, Centre for Vision Research, Westmead Hospital, University of Sydney, Sydney, New South Wales, Australia.
Clin Exp Ophthalmol. 2002 Jun;30(3):173-5. doi: 10.1046/j.1442-9071.2002.00519.x.
This study aimed to assess the influence of age on intraocular pressure(IOP) in a general population. The Blue Mountains Eye Study assessed 3654 residents aged 49+ years during 1992-1994. Intraocular pressure was measured using Goldmann applanation tonometry. Subjects with glaucoma, those currently on glaucoma medications and those with a history of cataract surgery were excluded. The IOP was reliably measured in 3260 subjects. Mean IOP was 16.0 mmHg with no significant difference found between men and women (P < 0.89). In univariate analyses, age was positively associated with IOP (P < 0.05). Systolic blood pressure (SBP) was strongly positively associated with IOP (P < 0.001). After adjusting for SBP, there was a trend for IOP to decrease with increasing age(P < 0.051). After further adjusting for other potential confounders (diabetes, glaucoma family history and myopia), age was no longer significantly associated with intraocular pressure (P < 0.29). In summary,no evidence was found of an independent age affect on IOP.
本研究旨在评估年龄对普通人群眼压（IOP）的影响。蓝山眼研究在1992年至1994年期间对3654名年龄在49岁及以上的居民进行了评估。使用Goldmann压平眼压计测量眼压。排除患有青光眼的受试者、目前正在使用青光眼药物的受试者以及有白内障手术史的受试者。在3260名受试者中可靠地测量了眼压。平均眼压为16.0 mmHg，男性和女性之间未发现显著差异（P < 0.89）。在单变量分析中，年龄与眼压呈正相关（P < 0.05）。收缩压（SBP）与眼压呈强烈正相关（P < 0.001）。在对SBP进行调整后，眼压有随着年龄增长而降低的趋势（P < 0.051）。在进一步调整其他潜在混杂因素（糖尿病、青光眼家族史和近视）后，年龄与眼压不再显著相关（P < 0.29）。总之，未发现年龄对眼压有独立影响的证据。
