Meza-Mauricio Jonathan, Furquim Camila-Pinheiro, Dos Reis Leonardo-Delfino, Maximiano Marlon-Marx-Hilariano, Mendoza-Azpur Gerardo, Muniz Francisco-Wilker-Mustafa-Gomes, Rasperini Giulio, Faveri Marcelo
Department of Periodontology, School of dentistry Universidad Cientifica del Sur Lima Peru.
Department of Periodontology and Oral Implantology, Dental Research Division, University of Guarulhos, SP, Brazil.
J Clin Exp Dent. 2022 Aug 1;14(8):e678-e688. doi: 10.4317/jced.59087. eCollection 2022 Aug.
A systematic review (SR) was conducted to answer the following focused question based on PICO strategy: In patients who were submitted to horizontal guided bone regeneration, "how efficacious is the combination of substitute bone graft with autogenous bone graft in comparison with substitute bone graft alone, in terms of bone gain?"
MEDLINE (PubMed), Scopus, Embase, Web of Science databases were searched, and hand searches were made up to June 2021, to find randomized clinical trials comparing the clinical effects of autogenous bone graft + substitute bone graft versus substitute bone graft alone in the treatment of horizontal guided bone regeneration.
Four trials representing 109 individuals were included. All studies included in this SR used allogeneic bone graft. The meta-analysis did not show any statistically significant difference between the groups, for horizontal bone gain at a distance of 0 mm (MD: -0.46; 95%CI: -1.03 - 0.11) or at a distance of 4 to 5 mm from the top of the crestal alveolar ridge (MD: 0.17; 95%CI: -1.08 - 1.42).
Within limitations of this systematic review, it was concluded that the addition of autogenous bone graft to the allogeneic bone graft did not significantly increase the quantity of regenerated bone. Bone graft, bone regeneration, allograft.
基于PICO策略进行了一项系统评价（SR），以回答以下重点问题：在接受水平引导骨再生的患者中，“与单独使用替代骨移植相比，替代骨移植与自体骨移植联合使用在骨增量方面的效果如何？”
检索了MEDLINE（PubMed）、Scopus、Embase、Web of Science数据库，并进行了手工检索，截止到2021年6月，以寻找比较自体骨移植+替代骨移植与单独使用替代骨移植在水平引导骨再生治疗中临床效果的随机临床试验。
纳入了四项试验，共109例个体。本系统评价纳入的所有研究均使用了同种异体骨移植。荟萃分析显示，两组之间在距牙槽嵴顶0 mm处（MD：-0.46；95%CI：-1.03 - 0.11）或距牙槽嵴顶4至5 mm处的水平骨增量方面，没有任何统计学上的显著差异（MD：0.17；95%CI：-1.08 - 1.42）。
在本系统评价的局限性范围内，得出的结论是，在同种异体骨移植中添加自体骨移植并不会显著增加再生骨的量。骨移植、骨再生、同种异体移植。
