黄芪总苷的抗衰老作用及其作用机制。
Anti-aging effect of astragalosides and its mechanism of action.
作者信息
Lei Hong, Wang Bin, Li Wei-Ping, Yang Yan, Zhou Ai-Wu, Chen Min-Zhu
机构信息
Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032, China.
出版信息
Acta Pharmacol Sin. 2003 Mar;24(3):230-4.
AIM
To study the anti-aging effect of astragalosides (AST) and its mechanism of action.
METHODS
Rotating rod test and step-down type passive avoidance test were performed to determine the effects of AST on motor and memory of D-galactose (D-gal)-induced senescent mice and the middle-aged mice. The proliferative response of splenocytes induced by Con A or LPS, IL-2 production of splenocytes induced by ConA of D-gal-treated mice and the middle-aged mice were also measured.
RESULTS
AST (40 mg.kg(-1).d(-1), ig, for 10 weeks) was found to ameliorate age-related alternations in both motor response and memory, enhance the deteriorated cellular immunity in D-gal-treated mice and the pre-aged (17-month-old) mice.
CONCLUSION
AST has an anti-aging effect on D-gal-induced senescent mice and has the effect of delaying senility of the middle-aged mice, which was related to its improvement of brain function and immunomodulatory effects.
目的
研究黄芪总苷（AST）的抗衰老作用及其作用机制。
方法
采用转棒试验和跳台法被动回避试验，观察AST对D-半乳糖（D-gal）致衰老小鼠及中年小鼠运动能力和记忆能力的影响。检测刀豆蛋白A（Con A）或脂多糖（LPS）诱导的脾细胞增殖反应、D-gal处理小鼠及中年小鼠Con A诱导的脾细胞白细胞介素-2（IL-2）产生水平。
结果
AST（40 mg·kg⁻¹·d⁻¹，灌胃，共10周）可改善衰老相关的运动反应和记忆能力的改变，增强D-gal处理小鼠及早衰（17月龄）小鼠衰退的细胞免疫功能。
结论
AST对D-gal诱导的衰老小鼠具有抗衰老作用，对中年小鼠具有延缓衰老的作用，这与其改善脑功能及免疫调节作用有关。
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