Van Rhijn Ildiko, Van den Berg Leonard H, Ang C Wim, Admiraal Joke, Logtenberg T
Departments of Neurology and Immunology, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands.
Int Immunol. 2003 Mar;15(3):373-82. doi: 10.1093/intimm/dxg041.
Campylobacter jejuni is currently the prime cause of food-borne bacterial gastro-enteritis. An important complication of C. jejuni enteritis is Guillain-Barré syndrome (GBS), an immune-mediated disorder of peripheral nerve tissue. Because little is known about T cell reactivity to C. jejuni, we have analyzed the in vitro immune response of normal individuals against five isolates of C. jejuni representing five different serotypes. We found a preferential expansion of peripheral blood gammadelta T cells after exposure to crude sonicates of all five C. jejuni serotypes. Expansion of gammadelta T cells was dependent on the presence of CD4+/alphabeta+ T cells in the cultures or addition of exogenous IL-2 or IL-15. C. jejuni stimulation was mediated via the TCR and appeared to be induced by a non-proteinaceous bacterial antigen, most likely of phosphoantigenic origin.
空肠弯曲菌是目前食源性细菌性肠胃炎的主要病因。空肠弯曲菌肠炎的一个重要并发症是吉兰 - 巴雷综合征（GBS），这是一种免疫介导的周围神经组织疾病。由于对T细胞对空肠弯曲菌的反应了解甚少，我们分析了正常个体对代表五种不同血清型的五株空肠弯曲菌的体外免疫反应。我们发现，暴露于所有五种空肠弯曲菌血清型的粗超声裂解物后，外周血γδ T细胞优先扩增。γδ T细胞的扩增依赖于培养物中CD4 + /αβ + T细胞的存在或添加外源性IL - 2或IL - 15。空肠弯曲菌刺激是通过TCR介导的，并且似乎是由一种非蛋白质细菌抗原诱导的，最有可能起源于磷酸抗原。
