Niamtu Joseph
Oral/Maxillofacial and Cosmetic Facial Surgery, 10230 Cherokee Rd, Richmond, VA 23235, USA.
J Oral Maxillofac Surg. 2003 Mar;61(3):317-24. doi: 10.1053/joms.2003.50069.
Botulinum toxin A (Botox; Allergan, Inc, Irvine, CA) has been used safely and effectively for the management of rhytids and dynamic lines of the face. Much of the initial anecdotal experience with Botox has changed with experience and is reported by the author.
In a 56-month period, 439 vials of Botox were used for primarily cosmetic improvement of facial lines and rhytids. Four hundred seventeen patients underwent 1,085 treatment episodes with an estimated 17,000 injections that were tracked on a database and reviewed.
Botox is a safe and effective treatment for the temporary improvement of facial lines and dynamic rhytids in selected anatomic regions. The techniques of reconstitution, storage, use, dose, and technique may not be as sensitive as originally described.
When following minimal guidelines, the use of Botox for cosmetic facial applications is safe, predictable, and without serious complications and provides generalized patient satisfaction.
A型肉毒毒素（保妥适；艾尔建公司，加利福尼亚州欧文市）已被安全有效地用于治疗面部皱纹和动态纹。作者报告了随着经验积累，许多最初关于保妥适的轶事性经验已发生变化。
在56个月的时间里，439瓶保妥适主要用于面部皱纹和细纹的美容改善。417名患者接受了1085次治疗，估计进行了17000次注射，并在数据库中进行跟踪和审查。
保妥适是一种安全有效的治疗方法，可暂时改善特定解剖区域的面部皱纹和动态皱纹。复溶、储存、使用、剂量和技术等方面可能不像最初描述的那样敏感。
遵循最低指导原则时，保妥适用于面部美容应用是安全、可预测的，且无严重并发症，并能使患者普遍满意。
