Cherpes Thomas L, Kusne Shimon, Hillier Sharon L
Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Infect Dis Obstet Gynecol. 2002;10(3):161-4. doi: 10.1155/S1064744902000170.
Haemophilus influenzae septic abortion is typically caused by nontypeable strains of the organism. Furthermore, nontypeable species with a special affinity for the genital tract are the most frequent isolates encountered, and an ascending vaginal or cervical infection is often the suspected route of transmission.
A 39-year-old woman at 8 weeks gestation who underwent dilation, evacuation, and curettage for embryonic demise had clinical evidence for sepsis and isolation of a nontypeable, ampicillin resistant H. influenzae from blood cultures. Although an ascending vaginal infection was suspected, the route of transmission was not determined.
Nontypeable strains of. H. influenzae have demonstrated increased beta-lactamase activity, and ampicillin, formerly the treatment of choice, should be used only if isolate susceptibility is known.
流感嗜血杆菌性脓毒性流产通常由该菌的不可分型菌株引起。此外，对生殖道有特殊亲和力的不可分型菌株是最常分离出的菌株，上行性阴道或宫颈感染常被怀疑为传播途径。
一名妊娠8周的39岁女性因胚胎死亡接受了扩张、刮宫及清宫术，有败血症的临床证据，血培养分离出一株不可分型、对氨苄西林耐药的流感嗜血杆菌。尽管怀疑有上行性阴道感染，但传播途径未明确。
流感嗜血杆菌的不可分型菌株已显示出增加的β-内酰胺酶活性，以前作为首选治疗药物的氨苄西林，仅在已知分离株敏感性时才可使用。
