Emerg Infect Dis. 2022 Sep;28(9):1749-1754. doi: 10.3201/eid2809.220313.
Invasive Haemophilus influenzae infection during pregnancy can cause preterm birth and fetal loss, but the mechanism is unclear. We investigated 54 cases of pregnancy-associated invasive H. influenzae disease in 52 unique pregnancies in the Auckland region of New Zealand during October 1, 2008‒September 30, 2018. Intraamniotic infection was identified in 36 (66.7%) of 54 cases. Outcome data were available for 48 pregnancies. Adverse pregnancy outcomes, defined as fetal loss, preterm birth, or the birth of an infant requiring intensive/special care unit admission, occurred in 45 (93.8%) of 48 (pregnancies. Fetal loss occurred in 17 (35.4%) of 48 pregnancies, before 24 weeks' gestation in 13 cases, and at >24 weeks' gestation in 4 cases. The overall incidence of pregnancy-associated invasive H. influenzae disease was 19.9 cases/100,000 births, which exceeded the reported incidence of pregnancy-associated listeriosis in New Zealand. We also observed higher rates in younger women and women of Māori ethnicity.
在怀孕期间，侵袭性流感嗜血杆菌感染可导致早产和胎儿丢失，但具体机制尚不清楚。我们调查了 2008 年 10 月 1 日至 2018 年 9 月 30 日期间新西兰奥克兰地区 52 例独特妊娠中与妊娠相关的侵袭性流感嗜血杆菌病的 54 例病例。在 54 例病例中，有 36 例（66.7%）存在羊膜内感染。有 48 例妊娠的结局数据可用。不良妊娠结局定义为胎儿丢失、早产或出生的婴儿需要重症/特别护理病房入院，在 48 例（93.8%）妊娠中发生了 45 例（93.8%）。在 48 例妊娠中，有 17 例（35.4%）发生了胎儿丢失，其中 13 例发生在 24 周妊娠之前，4 例发生在 24 周妊娠之后。与妊娠相关的侵袭性流感嗜血杆菌病的总发生率为每 100,000 例活产 19.9 例，超过了新西兰报道的与妊娠相关的李斯特菌病的发病率。我们还观察到，年轻女性和毛利族裔女性的发病率更高。
