Bentley R T, Burcham G N, Heng H G, Levine J M, Longshore R, Carrera-Justiz S, Cameron S, Kopf K, Miller M A
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.
Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.
Vet Comp Oncol. 2016 Sep;14(3):318-30. doi: 10.1111/vco.12106. Epub 2014 Jun 19.
The primary study objective was to determine whether clinical examination and magnetic resonance imaging (MRI) can underestimate canine gliomatosis cerebri (GC); we also investigated immunohistochemical features. Seven dogs with GC were studied; four recruited specifically because of minimal MRI changes. Neuroanatomic localization and the distribution of MRI, gross and sub-gross lesions were compared with the actual histological distribution of neoplastic cells. In six cases, clinical examination predicted focal disease and MRI demonstrated a single lesion or appeared normal. Neoplastic cells infiltrated many regions deemed normal by clinical examination and MRI, and were Olig2-positive and glial fibrillary acid protein-negative. Four dogs had concurrent gliomas. GC is a differential diagnosis for dogs with focal neurological deficits and a normal MRI or a focal MRI lesion. Canine GC is probably mainly oligodendrocytic. Type II GC, a solid glioma accompanying diffuse central nervous system neoplastic infiltration, occurs in dogs as in people.
主要研究目的是确定临床检查和磁共振成像（MRI）是否会低估犬脑胶质瘤病（GC）；我们还研究了免疫组化特征。对7只患有GC的犬进行了研究；其中4只因MRI变化极小而被专门招募。将神经解剖定位以及MRI、大体和亚大体病变的分布与肿瘤细胞的实际组织学分布进行了比较。在6例病例中，临床检查预测为局灶性疾病，MRI显示为单个病变或表现正常。肿瘤细胞浸润了许多经临床检查和MRI判定为正常的区域，且为少突胶质细胞转录因子2（Olig2）阳性和胶质纤维酸性蛋白（GFAP）阴性。4只犬同时患有胶质瘤。GC是对有局灶性神经功能缺损且MRI正常或有局灶性MRI病变的犬的鉴别诊断。犬GC可能主要为少突胶质细胞性。II型GC，即伴有弥漫性中枢神经系统肿瘤浸润的实体胶质瘤，在犬和人身上均有发生。
