青少年饮食与乳腺癌风险
Adolescent diet and risk of breast cancer.
作者信息
Frazier A Lindsay, Ryan Catherine Tomeo, Rockett Helaine, Willett Walter C, Colditz Graham A
机构信息
Division of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
出版信息
Breast Cancer Res. 2003;5(3):R59-64. doi: 10.1186/bcr583. Epub 2003 Feb 21.
BACKGROUND
Early life exposures, including diet, have been implicated in the etiology of breast cancer.
METHODS
A nested case-control study was conducted among participants in the Nurses' Health Study who completed a 24-item questionnaire about diet during high school. There were 843 eligible cases diagnosed between onset of study (1976) and before the return of the high school diet questionnaire (1986), who were matched 10:1 with controls on the basis of age.
RESULTS
Women who had, during adolescence, a higher consumption of eggs, vegetable fat and fiber had a lower risk of breast cancer, whereas risk of breast cancer was increased among women who consumed more butter.
CONCLUSIONS
A possible association of elements of adolescent diet with risk of breast cancer is reported, but the findings require confirmation in prospective study.
背景
包括饮食在内的早期生活暴露因素与乳腺癌的病因有关。
方法
在护士健康研究的参与者中进行了一项巢式病例对照研究，这些参与者完成了一份关于高中时期饮食的24项问卷。在研究开始（1976年）至高中饮食问卷返回之前（1986年）期间，有843例符合条件的病例被诊断出来，这些病例按照年龄以10:1的比例与对照组进行匹配。
结果
在青春期摄入较多鸡蛋、植物脂肪和纤维的女性患乳腺癌的风险较低，而摄入较多黄油的女性患乳腺癌的风险增加。
结论
报告了青少年饮食因素与乳腺癌风险之间可能存在的关联，但这些发现需要在前瞻性研究中得到证实。
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