Lubin J H, Burns P E, Blot W J, Ziegler R G, Lees A W, Fraumeni J F
Int J Cancer. 1981 Dec;28(6):685-9. doi: 10.1002/ijc.2910280605.
As part of a case-control study in northern Alberta, Canada, 577 women aged 30-80 with breast cancer diagnosed during 1976-77 and a population-based age-stratified random sample of 826 disease-free female controls were questioned about certain aspects of their diet. Computing relative risks (RRs) by tertiles, significant increasing trends were found with more frequent consumption of beef (RRs of 1.0, 2.3, 1.5; test for trends, p less than 0.001), pork (RRs of 1.0, 1.6, 2.2; test for trend, p less than 0.001), and sweet desserts (RRs of 1.0, 1.3, 1.5; test for trend, p = 0.01). Elevated risks were also noted for use of butter at the table and for frying with butter or margarine, as opposed to vegetable oils. The association of total beef and pork consumption with breast cancer was not materially affected by controlling for age at first birth, family history of breast cancer, previous benign breast biopsy or socioeconomic status. Nor was the association reduced by controlling for ages of menarche and menopause, even though within the control series the intake of beef and pork reported in adult life was higher among those with a lower age at menarche or a older age at natural menopause.
作为加拿大艾伯塔省北部一项病例对照研究的一部分，对1976年至1977年期间确诊的577名年龄在30至80岁之间的乳腺癌女性患者以及826名无病女性对照组成的基于人群的年龄分层随机样本进行了饮食方面的询问。通过三分位数计算相对风险（RRs），发现牛肉（RRs分别为1.0、2.3、1.5；趋势检验，p<0.001）、猪肉（RRs分别为1.0、1.6、2.2；趋势检验，p<0.001）和甜点心（RRs分别为1.0、1.3、1.5；趋势检验，p = 0.01）摄入频率越高，风险显著增加。与植物油相比，食用餐用黄油以及用黄油或人造黄油煎炸也会增加风险。控制首次生育年龄、乳腺癌家族史、既往良性乳腺活检或社会经济地位后，牛肉和猪肉总消费量与乳腺癌的关联没有受到实质性影响。控制初潮和绝经年龄后，这种关联也没有减弱，尽管在对照组中，初潮年龄较低或自然绝经年龄较大的女性在成年期报告的牛肉和猪肉摄入量较高。
