Wang Xiao-Chen, Gui Chang-Qing, Zheng Qing-Shan
Anhui Provincial Center for Drug Clinical Evaluation and Yijishan Hospital of Wanan Medical Collage, 93 TuanJieDong Lu, Wuhu 241001, Anhui Province, China.
World J Gastroenterol. 2003 Mar;9(3):568-71. doi: 10.3748/wjg.v9.i3.568.
To observe the preventive effects of combined therapy of AMD (allantoin, metronidazolem and dexamethasone in combination) on intra-abdominal adhesion in dogs.
20 dogs of both sexes were used in this study. After laparotomy under anesthesia, 2 cm section of cecal end was clamped and ligated, then 1 cm cecum section was cut and another 1 cm was kept. The cecum stump was closed with purse-string suture. Both parietal and visceral peritonea were stripped for an area of about 3X4 cm(2). Before the skin closure, the animals were divided into two groups randomly. The abdominal cavities in Group AMD (n=10) were rinsed by 200 ml of AMD solution, and with 50 ml left, whereas the control (n=10) received the equal volume of normal saline. After 7 d, the degree of intra-abdominal adhesions was evaluated by using the score method of ultrasonography and traditional dissection.
Compared with the control, both the ultrasonography and traditional dissection scores in Group AMD were significantly decreased that marked as 2.0+/-1.25 vs 3.3+/-0.82 and 1.91+/-0.83 vs 3.3+/-0.82 respectively (P<0.01).
The combined therapy of AMD is an effective way to prevent intra-abdominal adhesion, and ultrasonography is an useful tool to diagnose intra-abdominal adhesion.
观察AMD（尿囊素、甲硝唑和地塞米松联合制剂）联合治疗对犬腹腔粘连的预防作用。
本研究使用20只雌雄不限的犬。麻醉下剖腹后，钳夹并结扎盲肠末端2 cm节段，然后切除1 cm盲肠节段，保留另1 cm。用荷包缝合关闭盲肠残端。将壁层和脏层腹膜剥离约3×4 cm²的面积。在关闭皮肤前，将动物随机分为两组。AMD组（n = 10）腹腔用200 ml AMD溶液冲洗，剩余50 ml，而对照组（n = 10）接受等量生理盐水冲洗。7 d后，采用超声检查评分法和传统解剖法评估腹腔粘连程度。
与对照组相比，AMD组的超声检查评分和传统解剖评分均显著降低，分别为2.0±1.25 vs 3.3±0.82和1.91±0.83 vs 3.3±0.82（P < 0.01）。
AMD联合治疗是预防腹腔粘连的有效方法，超声检查是诊断腹腔粘连的有用工具。
