抗粘连制剂对兔术后腹腔渗出液中游离纤维蛋白原和纤维蛋白降解产物的影响。
Effects of Antiadhesion preparation on free fibrinogen and fibrin degrading products in abdominal exudates of rabbits postoperatively.
作者信息
Wang You-Li, Pan Cheng-En, Yang Ping-Lin, Tian Yuan, Pei Shu-Wen, Dong Ming
机构信息
Department of Hepatobiliary Surgery, Xi'an Jiaotong University First Hospital, Xi'an 710061, Shaanxi Providence, China.
出版信息
World J Gastroenterol. 2004 Sep 15;10(18):2762-6. doi: 10.3748/wjg.v10.i18.2762.
AIM
To observe effects of ACOL on fibrinogen (FIB), fibrin degrading products (FDP) and changes of FIB and FDP concentration in rabbits with intro-abdominal exudates during 7 d after major abdominal surgery.
METHODS
Sixty New Zealand rabbits were randomly divided into 4 groups: ACOL group, the control group, DCT group and the normal group. After being modeled, except the normal group, the other 3 groups were treated with different ways for a week; the intro-abdominal exudates of rabbits in the 4 groups were drawn for FIB and FDP measurement once daily during 7 d after major abdominal surgery.
RESULTS
FIB and FDP in the intro-abdominal exudates altered in a regular way and ACOL could change the concentration of FIB and FDP in the intra-abdominal exudates after major abdominal surgery.
CONCLUSION
ACOL can prevent intestinal adhesion by reducing the concentration of FIB and raising that of FDP in the intro-abdominal exudates after major abdominal surgery.
目的
观察腹部大手术后7天内，ACOL对家兔腹腔内渗出液中纤维蛋白原（FIB）、纤维蛋白降解产物（FDP）及FIB和FDP浓度变化的影响。
方法
将60只新西兰兔随机分为4组：ACOL组、对照组、DCT组和正常组。造模后，除正常组外，其他3组采用不同方法治疗1周；在腹部大手术后7天内，每天抽取4组家兔的腹腔内渗出液进行FIB和FDP检测。
结果
腹腔内渗出液中的FIB和FDP呈规律性变化，ACOL可改变腹部大手术后腹腔内渗出液中FIB和FDP的浓度。
结论
ACOL可通过降低腹部大手术后腹腔内渗出液中FIB的浓度、提高FDP的浓度来预防肠粘连。
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