Kohut Maciej, Nowak Andrzej, Nowakowska-Dulawa Ewa, Marek Tomasz, Kaczor Roman
Gastroenterology Department of Silesian Medical Academy, Katowice, Poland.
World J Gastroenterol. 2003 Mar;9(3):612-4. doi: 10.3748/wjg.v9.i3.612.
To evaluate the diagnostic efficiency of endoscopic ultrasound (EUS) as the main imaging modality in patients with moderate suspicion of common bile duct stones (CBDS).
55 patients with moderate clinical suspicion of CBDS were prospectively included to the study and evaluated with EUS. This study was done in single blind method in the clinical and biochemical data of patients. EUS was done with echo-endoscope Pentax FG 32-UA (f=5-7.5 MHz) and Hitachi EUB 405 ultrasound machine. Patients diagnosed with CBDS by EUS were excluded from this study and treated with ERC. All the other patients were included to the follow up study obtained by mail every 6 months for clinical evaluation (need of ERC or surgery).
CBDS was found in 4 patients by EUS. Diagnosis was confirmed in all cases on ERC. The remaining 51 patients without CBDS on EUS were followed up for 6-26 months (meanly 13 months) There were: 40 women, 42 cholecystectomized patients, aged: 55 (mean). Biochemical values (mean values) were as follows: bilirubin: 14.9 micromol/L, alkaline phosphatase: 95 IU/L(-1), gamma-GTP: 131 IU/L(-1), ALT: 50 IU/L(-1), AST: 49 IU/L(-1)(-1). Only 1 patient was lost for follow up. In the remaining 50 patients with follow up, there was only 1 (2 %) patient with persistent biliary symptoms in whom CBDS was finally diagnosed by ERC with ES. All other patients remained symptoms free on follow up and did not require ERC or biliary surgery.
Vast majority of patients with moderate suspicion of CBDS and no stones on EUS with linear array can avoid invasive evaluation of biliary tree with ERC.
评估内镜超声(EUS)作为对胆总管结石(CBDS)中度怀疑患者主要成像方式的诊断效能。
前瞻性纳入55例临床中度怀疑CBDS的患者,并采用EUS进行评估。本研究对患者的临床和生化数据采用单盲法进行。使用宾得FG 32-UA型(f = 5 - 7.5 MHz)超声内镜和日立EUB 405超声仪进行EUS检查。经EUS诊断为CBDS的患者被排除在本研究之外,并接受内镜逆行胰胆管造影(ERC)治疗。所有其他患者被纳入随访研究,每6个月通过邮件进行临床评估(是否需要ERC或手术)。
EUS检查发现4例患者患有CBDS。所有病例经ERC均确诊。其余51例EUS检查未发现CBDS的患者随访6 - 26个月(平均13个月),其中有:40名女性,42例已行胆囊切除术的患者,年龄:55岁(平均)。生化指标(平均值)如下:胆红素:14.9微摩尔/升,碱性磷酸酶:95国际单位/升(-1),γ-谷氨酰转肽酶:131国际单位/升(-1),谷丙转氨酶:50国际单位/升(-1),谷草转氨酶:49国际单位/升(-1)(-1)。仅1例患者失访。在其余50例有随访的患者中,只有1例(2%)患者持续存在胆道症状,最终经ERC联合内镜括约肌切开术(ES)诊断为CBDS。所有其他患者在随访期间均无症状,无需ERC或胆道手术。
绝大多数临床中度怀疑CBDS且EUS线性阵列检查未发现结石的患者可避免采用ERC对胆道系统进行侵入性评估。