Lakatos Laszlo, Mester Gabor, Reti Gyorgy, Nagy Attila, Lakatos Peter Laszlo
1st Department of Medicine, Csolnoky F, Province Hospital, Veszprem, H-8200, Hungary.
World J Gastroenterol. 2004 Dec 1;10(23):3495-9. doi: 10.3748/wjg.v10.i23.3495.
The optimal treatment for bile duct stones (in terms of cost, complications and accuracy) is unclear. The aim of our study was to determine the predictive factors for preoperative endoscopic retrograde cholangiopancreatography (ERCP).
Patients undergoing preoperative ERCP (< or =90 d before laparoscopic cholecystectomy) were evaluated in this retrospective study from the 1st of January 1996 to the 31st of December 2002. The indications for ERCP were elevated serum bilirubin, elevated liver function tests (LFT), dilated bile duct (> or =8 mm) and/or stone at US examination, coexisting acute pancreatitis and/or acute pancreatitis or jaundice in patient's history. Suspected prognostic factors and the combination of factors were compared to the result of ERCP.
Two hundred and six preoperative ERCPs were performed during the observed period. The rate of successful cannulation for ERC was (97.1%). Bile duct stones were detected in 81 patients (39.3%), and successfully removed in 79 (97.5%). The number of prognostic factors correlated with the presence of bile duct stones. The positive predictive value for one prognostic factor was 1.2%, for two 43%, for three 72.5%, for four or more 91.4%.
Based on our data preoperative ERCP is highly recommended in patients with three or more positive factors (high risk patients). In contrast, ERCP is not indicated in patients with zero or one factor (low risk patients). Preoperative ERCP should be offered to patients with two positive factors (moderate risk patients), however the practice should also be based on the local conditions (e.g. skill of the endoscopist, other diagnostic tools).
胆管结石的最佳治疗方法(在成本、并发症和准确性方面)尚不清楚。我们研究的目的是确定术前内镜逆行胰胆管造影(ERCP)的预测因素。
对1996年1月1日至2002年12月31日期间接受术前ERCP(在腹腔镜胆囊切除术之前≤90天)的患者进行了这项回顾性研究。ERCP的指征包括血清胆红素升高、肝功能检查(LFT)升高、胆管扩张(≥8mm)和/或超声检查发现结石、并存急性胰腺炎和/或患者既往有急性胰腺炎或黄疸病史。将可疑的预后因素及因素组合与ERCP结果进行比较。
在观察期间共进行了206例术前ERCP。ERCP插管成功率为97.1%。81例患者(39.3%)检测到胆管结石,79例(97.5%)成功取出结石。预后因素的数量与胆管结石的存在相关。一个预后因素的阳性预测值为1.2%,两个为43%,三个为72.5%,四个或更多为91.4%。
根据我们的数据,强烈建议在具有三个或更多阳性因素的患者(高风险患者)中进行术前ERCP。相反,对于零个或一个因素的患者(低风险患者)不建议进行ERCP。对于具有两个阳性因素的患者(中度风险患者)应提供术前ERCP,然而实践也应基于当地情况(如内镜医师的技术、其他诊断工具)。