Marks L S, Maxwell M H, Varady P D, Lupu A N, Kaufman J J
J Urol. 1976 Apr;115(4):365-8. doi: 10.1016/s0022-5347(17)59206-x.
Renal vein renin ratios from 56 hypertensive patients who were operated upon for unilateral stenosis of a main renal artery were compared to blood pressure response to a corrective operation. In patients with renal vein renin ratios greater then 2.0, the upper limits of normal for essential hypertension (95 per cent confidence limits), the cure/improvement rate approximated 90 per cent. However, in patients operated upon despite lesser ratios the cure/improvement rate was also high--83 per cent in our series and 57 per cent in collected reports from the literature. Thus, the test may be falsely negative in a high percentage of patients. Renal vein renin ratios would appear to be most useful in confirming but not necessarily in denying the functional significance of a renal artery stenosis.
对56例因主肾动脉单侧狭窄而接受手术的高血压患者的肾静脉肾素比值，与矫正手术后的血压反应进行了比较。在肾静脉肾素比值大于2.0（原发性高血压正常上限，95%置信区间）的患者中，治愈/改善率约为90%。然而，在肾素比值较低时接受手术的患者中，治愈/改善率也很高——在我们的系列研究中为83%，在文献收集报告中为57%。因此，该检测在高比例患者中可能出现假阴性。肾静脉肾素比值似乎在证实肾动脉狭窄的功能意义方面最为有用，但不一定能排除其功能意义。
