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钯催化的醇的对映选择性氧化：碳酸铯/叔丁醇显著加速反应速率

Palladium-catalyzed enantioselective oxidation of alcohols: a dramatic rate acceleration by Cs2CO3/t-BuOH.

作者信息

Bagdanoff Jeffrey T, Ferreira Eric M, Stoltz Brian M

机构信息

The Arnold and Mabel Beckman Laboratories of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

出版信息

Org Lett. 2003 Mar 20;5(6):835-7. doi: 10.1021/ol027463p.

DOI:10.1021/ol027463p
PMID:12633084
Abstract

[reaction: see text] The addition of Cs(2)CO(3) and t-BuOH provides a dramatic rate acceleration in the palladium-catalyzed aerobic oxidative kinetic resolution of secondary alcohols while maintaining the selectivity of the process.

摘要

[反应：见正文] 碳酸铯（Cs₂CO₃）和叔丁醇（t-BuOH）的加入在钯催化的仲醇需氧氧化动力学拆分中显著加快了反应速率，同时保持了该过程的选择性。

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