Permar Sallie R, Klumpp Sherry A, Mansfield Keith G, Kim Woong-Ki, Gorgone Darci A, Lifton Michelle A, Williams Kenneth C, Schmitz Jörn E, Reimann Keith A, Axthelm Michael K, Polack Fernando P, Griffin Diane E, Letvin Norman L
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
J Virol. 2003 Apr;77(7):4396-400. doi: 10.1128/jvi.77.7.4396-4400.2003.
The creation of an improved vaccine for global measles control will require an understanding of the immune mechanisms of measles virus containment. To assess the role of CD8(+) cytotoxic T lymphocytes in measles virus clearance, rhesus monkeys were depleted of CD8(+) lymphocytes by monoclonal anti-CD8 antibody infusion and challenged with wild-type measles virus. The CD8(+) lymphocyte-depleted animals exhibited a more extensive rash, higher viral loads at the peak of virus replication, and a longer duration of viremia than did the control antibody-treated animals. These findings indicate a central role for CD8(+) lymphocytes in the control of measles virus infections and the importance of eliciting a cell-mediated immune response in new measles vaccine strategies.
开发一种用于全球麻疹控制的改良疫苗需要了解控制麻疹病毒的免疫机制。为了评估CD8(+) 细胞毒性T淋巴细胞在麻疹病毒清除中的作用，通过输注单克隆抗CD8抗体使恒河猴的CD8(+) 淋巴细胞耗竭，然后用野生型麻疹病毒进行攻击。与接受对照抗体治疗的动物相比，CD8(+) 淋巴细胞耗竭的动物出现了更广泛的皮疹，在病毒复制高峰期病毒载量更高，病毒血症持续时间更长。这些发现表明CD8(+) 淋巴细胞在控制麻疹病毒感染中起核心作用，以及在新的麻疹疫苗策略中引发细胞介导免疫反应的重要性。
