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[银屑病的局部治疗:系统更新]

[Topical treatment of psoriasis: a systematic update].

作者信息

Aschoff R, Wozel G, Meurer M

机构信息

Klinik und Poliklinik für Dermatologie, Universitätsklinikum Carl Gustav Carus Dresden an der Technischen Universität Dresden.

出版信息

Hautarzt. 2003 Mar;54(3):237-41. doi: 10.1007/s00105-003-0498-1. Epub 2003 Feb 13.

Abstract

Classical topical treatment regimens in psoriasis including dithranol and corticosteroids are widely used and have been supplemented in recent years by topical vitamin D preparations, by vitamin D analogues and topical retinoids. The combination of these preparations with each other, with UV light or with systemic drugs often lead to improved effectiveness and tolerability when compared with the respective monotherapy. In private offices, the combination of calcipotriol with various corticosteroids is very commonly prescribed for patients with mild to moderate psoriasis. This combination can be sequentially applied twice daily or--in a newly introduced fixed preparation--once daily. In severe psoriasis requiring systemic treatment a concomitant effective topical treatment regimen can greatly improve the overall longtime management in affected patients.

摘要

银屑病的经典局部治疗方案,包括地蒽酚和皮质类固醇,应用广泛,近年来又补充了局部维生素D制剂、维生素D类似物和局部维甲酸。与各自的单一疗法相比,这些制剂相互之间、与紫外线或与全身药物联合使用,往往能提高疗效和耐受性。在私人诊所,钙泊三醇与各种皮质类固醇的联合用药常用于治疗轻至中度银屑病患者。这种联合用药可以每天分两次序贯使用,或者——在新推出的固定制剂中——每天使用一次。在需要全身治疗的重度银屑病中,同时采用有效的局部治疗方案可以大大改善对受影响患者的长期整体管理。

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