Hashimoto Shigeatsu, Yatabe Jun-ichi, Midorikawa Sanae, Sanada Hironobu, Watanabe Tsuyoshi
3rd Department of Internal Medicine, Fukushima Medical University, School of Medicine, Fukushima, Japan.
Horm Res. 2003;59(3):149-55. doi: 10.1159/000069064.
A 23-year-old female with polycystic ovary syndrome (PCOS) and a growth-hormone (GH)-producing pituitary adenoma is described. A reduction in the elevated GH levels to normal levels following the administration of dopaminergic agents decreased plasma insulin-like growth factor (IGF)-1 and ovarian dysfunction. Menstrual cycles were therefore restored and the number of ovarian cysts reduced, suggesting that insulin and/or IGF-1, stimulators of theca cell proliferation, may be pathogenetic factors in PCOS.
本文描述了一名患有多囊卵巢综合征（PCOS）且伴有分泌生长激素（GH）的垂体腺瘤的23岁女性。给予多巴胺能药物后，升高的GH水平降至正常水平，血浆胰岛素样生长因子（IGF）-1降低，卵巢功能障碍改善。月经周期得以恢复，卵巢囊肿数量减少，这表明胰岛素和/或IGF-1作为卵泡膜细胞增殖的刺激因子，可能是PCOS的致病因素。
