一项随机双盲研究，比较三种不同剂量的利多卡因在取卵时用于宫颈旁阻滞的有效性。
A randomized double-blind study to compare the effectiveness of three different doses of lignocaine used in paracervical block during oocyte retrieval.
作者信息
Ng Ernest Hung Yu, Miao Benyu, Ho Pak Chung
机构信息
Department of Obstetrics and Gynecology, The University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China.
出版信息
J Assist Reprod Genet. 2003 Jan;20(1):8-12. doi: 10.1023/a:1021202604049.
PURPOSE
To compare the effectiveness of three different doses of lignocaine used in paracervical block (PCB) during transvaginal ultrasound-guided oocyte retrieval (TUGOR) METHODS: In this double-blind study, 153 patients undergoing TUGOR in their first in vitro fertilization cycle were randomized to receive 50, 100, and 150 mg of lignocaine in PCB. Pain levels were measured by a 100-mm linear visual analogue scale (0 = none to 100 = intolerable).
RESULTS
No differences were seen in the demographic data, the ovarian responses, the duration of TUGOR, and the number of follicles punctured. Vaginal and abdominal pain levels during TUGOR and 4 h after TUGOR were not significantly different among the three groups The median vaginal and abdominal pain levels during the retrieval were 22.0-24.0 and 30.0-32.0 respectively.
CONCLUSION
The use of 50 mg of lignocaine is recommended in PCB because of the lack of improvement in pain relief on higher doses and potential dose-related risks.
目的
比较三种不同剂量的利多卡因用于经阴道超声引导下取卵术（TUGOR）宫颈旁阻滞（PCB）的效果。方法：在这项双盲研究中，153例首次接受体外受精周期TUGOR的患者被随机分为三组，分别在PCB中接受50、100和150mg利多卡因。疼痛程度采用100mm线性视觉模拟量表进行测量（0表示无疼痛至100表示无法忍受）。结果：三组在人口统计学数据、卵巢反应、TUGOR持续时间和穿刺卵泡数量方面均无差异。TUGOR期间及TUGOR后4小时，三组的阴道和腹部疼痛程度无显著差异。取卵期间阴道和腹部疼痛程度的中位数分别为22.0 - 24.0和30.0 - 32.0。结论：由于高剂量利多卡因在缓解疼痛方面并无改善且存在潜在的剂量相关风险，因此建议在PCB中使用50mg利多卡因。
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