Gonen O, Shulman A, Ghetler Y, Shapiro A, Judeiken R, Beyth Y, Ben-Nun I
Department of Obstetrics and Gynecology, Sapir Medical Center, Kfar, Saba, Israel.
J Assist Reprod Genet. 1995 Nov;12(10):678-82. doi: 10.1007/BF02212892.
Our objective was to evaluate retrospectively the influence of different types of anesthesia on the outcome of ovum retrieval.
Sedation combined with local anesthesia was used on 120 occasions (Group I), epidural block in 139 ovum retrievals (Group II), and general anesthesia in 173 cycles (Group III).
No differences were found in embryo yield or number or the quality of the embryo transferred. Of 99 pregnancies achieved, 66 live deliveries were recorded. Significantly lower clinical pregnancy rates were found in Group III (14.5%) compared with Group II (23.7%; P = 0.018) or Group I (25.8%; P = 0.0074). Highly significant differences were found in the delivery rates between Group III (8.7%), Group II (20.11%; P = 0.0017), and Group I (19.2%; P = 0.0043).
The use of general anesthesia, especially nitrous oxide, for oocyte retrieval has an adverse effect on IVF outcome. This deleterious effect manifests itself only after embryo transfer and leads to lower pregnancy and delivery rates.
我们的目的是回顾性评估不同类型麻醉对取卵结果的影响。
120例采用镇静联合局部麻醉（I组），139例取卵采用硬膜外阻滞（II组），173个周期采用全身麻醉（III组）。
在获卵数、移植胚胎数或胚胎质量方面未发现差异。在99例妊娠中，记录到66例活产。与II组（23.7%；P = 0.018）或I组（25.8%；P = 0.0074）相比，III组的临床妊娠率显著降低（14.5%）。III组（8.7%）、II组（20.11%；P = 0.0017）和I组（19.2%；P = 0.0043）之间的分娩率存在高度显著差异。
采用全身麻醉，尤其是氧化亚氮进行卵母细胞取卵，对体外受精结果有不利影响。这种有害影响仅在胚胎移植后才显现出来，并导致较低的妊娠率和分娩率。
