Ella Foundation, Genome Valley, Turkapally, Shameerpet Mandal, Hyderabad 500 078, India.
Drug Discov Today. 2011 Dec;16(23-24):1061-8. doi: 10.1016/j.drudis.2011.07.004. Epub 2011 Jul 18.
Despite remarkable progress in the control of infectious diseases through vaccination, better delivery systems have been poorly explored. There is renewed interest in the discovery of novel vaccines and adjuvants owing to emerging and reemerging diseases and the burden and complexity of chronic infectious diseases. Conversely, the need for rapid local, regional, mucosal or parenteral bioavailability has led to advances in delivery systems and devices. Here, we present recent developments in the field of non-invasive cutaneous delivery of vaccines for infectious diseases. Transdermal delivery using microneedles could revolutionize the way prophylactic interventions for infectious diseases are carried out in the future.
尽管通过疫苗接种在控制传染病方面取得了显著进展，但更好的输送系统仍未得到充分探索。由于新发和再现传染病以及慢性传染病的负担和复杂性，人们对新型疫苗和佐剂的发现重新产生了兴趣。相反，对快速局部、区域、黏膜或肠胃外生物利用度的需求推动了输送系统和设备的进步。在这里，我们介绍了传染病非侵入性皮肤疫苗传递领域的最新进展。使用微针的经皮传递可能会彻底改变未来传染病预防性干预的实施方式。
