Drisko Jeanne A, Chapman Julia, Hunter Verda J
Department of Obstetrics and Gynecology, School of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Gynecol Oncol. 2003 Mar;88(3):434-9. doi: 10.1016/s0090-8258(02)00067-7.
At the present time, many cancer patients combine some form of complementary and alternative medicine therapies with their conventional therapies. The most common choice of these therapies is the use of antioxidants.
A review of four common antioxidants is undertaken, which includes vitamin E (mixed tocopherols and tocotrienols), beta-carotene (natural mixed carotenoids), vitamin C (ascorbic acid), and vitamin A (retinoic acid). Antioxidants act as electron acceptors as well as therapeutic biologic response modifiers. Despite the fact that chemotherapy-induced formation of free radicals is well-demonstrated, chemotherapy-induced cytotoxicity in general does not seem to depend on formation of reactive oxygen species.
Currently, evidence is growing that antioxidants may provide some benefit when combined with certain types of chemotherapy. Because of the potential for positive benefits, a randomized controlled trial evaluating the safety and efficacy of adding antioxidants to chemotherapy in newly diagnosed ovarian cancer is underway at the University of Kansas Medical Center.
目前，许多癌症患者在接受传统治疗的同时还会结合某种形式的补充和替代医学疗法。这些疗法中最常见的选择是使用抗氧化剂。
对四种常见的抗氧化剂进行了综述，包括维生素E（混合生育酚和生育三烯酚）、β-胡萝卜素（天然混合类胡萝卜素）、维生素C（抗坏血酸）和维生素A（视黄酸）。抗氧化剂既作为电子受体，又作为治疗性生物反应调节剂。尽管化疗诱导自由基形成已得到充分证实，但一般来说，化疗诱导的细胞毒性似乎并不取决于活性氧的形成。
目前，越来越多的证据表明，抗氧化剂与某些类型的化疗联合使用可能会带来一些益处。由于存在积极益处的可能性，堪萨斯大学医学中心正在进行一项随机对照试验，以评估在新诊断的卵巢癌化疗中添加抗氧化剂的安全性和有效性。
