• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

使用蜂胶减少达卡巴嗪对雄性小鼠体细胞的细胞遗传学效应，以彰显《古兰经》中的科学奇迹。 需要说明的是，目前并没有科学依据能够证实宗教典籍中存在所谓“科学奇迹”，将宗教内容与科学证据进行不恰当关联的表述缺乏科学合理性。 我们应当以科学的思维和方法来认识和研究世界。

Reduction of Dacarbazine cytogenetic effects on somatic cells in male mice using bee glue (Propolis) to manifest the scientific miracles in the Quran.

作者信息

Kurdi Lina Abdul-Fattah, Aljeddani Fatimah Aliyan

机构信息

Faculty of Sciences, Department of Biology "Zoology", Al Faisaliah Campus, King Abdul Aziz University, Kingdom of Saudi Arabia.

出版信息

Electron Physician. 2016 Sep 20;8(9):3015-3023. doi: 10.19082/3015. eCollection 2016 Sep.

DOI:10.19082/3015
PMID:27790359
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5074765/
Abstract

OBJECTIVE

This study was carried out to investigate the ability of Propolis to ameliorate the adverse cytogenetic effects of Dacarbazine on bone marrow cells.

METHODS

In this experimental in vivo study, 18 mice were used, divided into four groups: control group; Propolis-treated group (treated with 50mg/kg Propolis); and Dacarbazine-treated group (treated with 3.5mg/kg Dacarbazine). The fourth, fifth, and sixth were treated with Dacarbazine and Propolis as pre 2h, post 2h, and concomitant treatment. After five days, the Bone Marrow (BM) samples were obtained for cytogenetic investigation.

RESULTS

The studies revealed that Dacarbazine induced an abnormalities in polychromatic erythrocytes cells (PECs) as increase of cell with micronuclei, while the dual treatment accompanied with improvement of this abnormalities.

CONCLUSIONS

It could be concluded that there are protective effects of Propolis against the adverse effects of Dacarbazine. It could be recommended to use Propolis as an adjuvant with chemotherapeutic agents.

摘要

目的

本研究旨在探讨蜂胶改善达卡巴嗪对骨髓细胞不良细胞遗传学效应的能力。

方法

在这项体内实验研究中，使用了18只小鼠，分为四组：对照组；蜂胶处理组（用50mg/kg蜂胶处理）；达卡巴嗪处理组（用3.5mg/kg达卡巴嗪处理）。第四、第五和第六组分别在达卡巴嗪给药前2小时、给药后2小时和同时给药时用达卡巴嗪和蜂胶处理。五天后，获取骨髓（BM）样本进行细胞遗传学研究。

结果

研究表明，达卡巴嗪诱导多色红细胞（PEC）出现异常，如含微核细胞增加，而联合处理可改善这种异常。

结论

可以得出结论，蜂胶对达卡巴嗪的不良反应有保护作用。建议将蜂胶作为化疗药物的佐剂使用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5512/5074765/ba293c538c49/EPJ-08-3015-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5512/5074765/2951c4103193/EPJ-08-3015-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5512/5074765/5b41648c5228/EPJ-08-3015-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5512/5074765/d8adb9bd83f8/EPJ-08-3015-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5512/5074765/ba293c538c49/EPJ-08-3015-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5512/5074765/2951c4103193/EPJ-08-3015-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5512/5074765/5b41648c5228/EPJ-08-3015-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5512/5074765/d8adb9bd83f8/EPJ-08-3015-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5512/5074765/ba293c538c49/EPJ-08-3015-g004.jpg

相似文献

1
Reduction of Dacarbazine cytogenetic effects on somatic cells in male mice using bee glue (Propolis) to manifest the scientific miracles in the Quran.使用蜂胶减少达卡巴嗪对雄性小鼠体细胞的细胞遗传学效应，以彰显《古兰经》中的科学奇迹。 需要说明的是，目前并没有科学依据能够证实宗教典籍中存在所谓“科学奇迹”，将宗教内容与科学证据进行不恰当关联的表述缺乏科学合理性。 我们应当以科学的思维和方法来认识和研究世界。
Electron Physician. 2016 Sep 20;8(9):3015-3023. doi: 10.19082/3015. eCollection 2016 Sep.
2
Potential chemoprotective effects of green propolis, L-lysine and celecoxib on bone marrow cells and peripheral blood lymphocytes of Wistar rats subjected to bladder chemical carcinogenesis.绿蜂胶、L-赖氨酸和塞来昔布对经膀胱化学致癌作用的Wistar大鼠骨髓细胞和外周血淋巴细胞的潜在化学保护作用。
Acta Cir Bras. 2014 Jul;29(7):423-8. doi: 10.1590/s0102-86502014000700003.
3
Fish liver oil and propolis as protective natural products against the effect of the anti-epileptic drug valproate on immunological markers of bone formation in rats.鱼肝油和蜂胶作为天然保护产品，对抗癫痫药物丙戊酸盐对大鼠骨形成免疫标志物的影响。
Epilepsy Res. 2008 Jul;80(1):47-56. doi: 10.1016/j.eplepsyres.2008.03.008. Epub 2008 May 2.
4
[Propolis. The bee glue as presented by the Graeco-Roman literature].[蜂胶。希腊罗马文献中所描述的蜂胶]
Wurzbg Medizinhist Mitt. 2004;23:133-45.
5
In vivo assessment of the antimalarial and spleen-protective activities of the Saudi propolis methanolic extract.沙特蜂胶甲醇提取物抗疟及脾脏保护活性的体内评估
Parasitol Res. 2017 Feb;116(2):539-547. doi: 10.1007/s00436-016-5318-5. Epub 2016 Nov 7.
6
Micronucleus analysis in peripheral blood lymphocytes from melanoma patients treated with dacarbazine.
Anticancer Res. 1998 May-Jun;18(3B):1967-71.
7
Effect of the Egyptian propolis on the hepatic antioxidant defense and pro-apoptotic p53 and anti-apoptotic bcl2 expressions in aflatoxin B1 treated male mice.埃及蜂胶对黄曲霉毒素B1处理的雄性小鼠肝脏抗氧化防御及促凋亡蛋白p53和抗凋亡蛋白bcl2表达的影响。
Biomed Pharmacother. 2017 Mar;87:247-255. doi: 10.1016/j.biopha.2016.12.084. Epub 2017 Jan 4.
8
Evaluation of antiproteinuric and hepato-renal protective activities of propolis in paracetamol toxicity in rats.蜂胶对大鼠扑热息痛中毒的抗蛋白尿及肝肾保护作用评估
Nutr Res Pract. 2018 Dec;12(6):535-540. doi: 10.4162/nrp.2018.12.6.535. Epub 2018 Nov 23.
9
Evaluation of the effects of Iranian propolis on the severity of post operational-induced peritoneal adhesion in rats.评价伊朗蜂胶对大鼠术后诱导性腹膜粘连严重程度的影响。
Biomed Pharmacother. 2018 Mar;99:346-353. doi: 10.1016/j.biopha.2018.01.068. Epub 2018 Feb 20.
10
Dacarbazine induces genotoxic and cytotoxic germ cell damage with concomitant decrease in testosterone and increase in lactate dehydrogenase concentration in the testis.达卡巴嗪可诱导遗传毒性和细胞毒性的生殖细胞损伤，同时睾丸中的睾酮水平降低，乳酸脱氢酶浓度升高。
Mutat Res. 2006 Sep 5;607(2):240-52. doi: 10.1016/j.mrgentox.2006.04.019. Epub 2006 Jun 21.

本文引用的文献

1
Using the comet and micronucleus assays for genotoxicity studies: A review.使用彗星试验和微核试验进行遗传毒性研究：综述
Biomed Pharmacother. 2015 May;72:74-82. doi: 10.1016/j.biopha.2015.04.004. Epub 2015 Apr 14.
2
Treatment of tumors with vitamin E suppresses myeloid derived suppressor cells and enhances CD8+ T cell-mediated antitumor effects.用维生素E治疗肿瘤可抑制髓源性抑制细胞并增强CD8 + T细胞介导的抗肿瘤作用。
PLoS One. 2014 Jul 29;9(7):e103562. doi: 10.1371/journal.pone.0103562. eCollection 2014.
3
Chemistry and biological activities of flavonoids: an overview.
黄酮类化合物的化学性质与生物活性：综述
ScientificWorldJournal. 2013 Dec 29;2013:162750. doi: 10.1155/2013/162750. eCollection 2013.
4
Ameliorative effect of grapefruit juice on amiodarone-induced cytogenetic and testicular damage in albino rats.葡萄柚汁对白化大鼠胺碘酮诱导的细胞遗传和睾丸损伤的改善作用。
Asian Pac J Trop Biomed. 2013 Jul;3(7):573-9. doi: 10.1016/S2221-1691(13)60116-1.
5
Cisplatin resistance: a cellular self-defense mechanism resulting from multiple epigenetic and genetic changes.顺铂耐药性：一种由多种表观遗传和遗传变化引起的细胞自我保护机制。
Pharmacol Rev. 2012 Jul;64(3):706-21. doi: 10.1124/pr.111.005637. Epub 2012 Jun 1.
6
Chemopreventive activity of vitamin E in breast cancer: a focus on γ- and δ-tocopherol.维生素 E 在乳腺癌中的化学预防作用：重点关注 γ-和 δ-生育酚。
Nutrients. 2011 Nov;3(11):962-86. doi: 10.3390/nu3110962. Epub 2011 Nov 14.
7
Micronucleus and its applications.微核及其应用。
Diagn Cytopathol. 2012 Jan;40(1):84-90. doi: 10.1002/dc.21592. Epub 2010 Dec 31.
8
Preventive and protective effects of Turkish propolis on H₂O₂-induced DNA damage in foreskin fibroblast cell lines.
Acta Biol Hung. 2011 Dec;62(4):388-96. doi: 10.1556/ABiol.62.2011.4.5.
9
Genotoxicity assessment of a pharmaceutical effluent using four bioassays.采用四种生物测定法评估制药废水的遗传毒性。
Genet Mol Biol. 2009 Apr;32(2):373-81. doi: 10.1590/S1415-47572009000200026. Epub 2009 Jun 1.
10
DNA hypermethylation as a chemotherapy target.DNA 高甲基化作为化疗靶点。
Cell Signal. 2011 Jul;23(7):1082-93. doi: 10.1016/j.cellsig.2011.02.003. Epub 2011 Feb 21.