Malik Akshi, Bagchi Ashim K, Vinayak Kartik, Akolkar Gauri, Slezak Jan, Belló-Klein Adriane, Jassal Davinder S, Singal Pawan K
Department of Physiology and Pathophysiology, Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, University of Manitoba, 351 Tache Avenue, Winnipeg, MB, R2H 2A6, Canada.
University of Ottawa Heart Institute, Ottawa, Canada.
Heart Fail Rev. 2021 May;26(3):699-709. doi: 10.1007/s10741-020-10036-y. Epub 2020 Oct 8.
Vitamin C (Vit C) is an ideal antioxidant as it is easily available, water soluble, very potent, least toxic, regenerates other antioxidants particularly Vit E, and acts as a cofactor for different enzymes. It has received much attention due to its ability in limiting reactive oxygen species, oxidative stress, and nitrosative stress, as well as it helps to maintain some of the normal metabolic functions of the cell. However, over 140 clinical trials using Vit C in different pathological conditions such as myocardial infarction, gastritis, diabetes, hypertension, stroke, and cancer have yielded inconsistent results. Such a divergence calls for new strategies to establish practical significance of Vit C in heart failure or even in its prevention. For a better understanding of Vit C functioning, it is important to revisit its transport across the cell membrane and subcellular interactions. In this review, we have highlighted some historical details of Vit C and its transporters in the heart with a particular focus on heart failure in cancer chemotherapy.
维生素C（Vit C）是一种理想的抗氧化剂，因为它易于获取、水溶性好、抗氧化能力强、毒性最小、能再生其他抗氧化剂，尤其是维生素E，并且作为不同酶的辅助因子发挥作用。由于其在限制活性氧、氧化应激和亚硝化应激方面的能力，以及有助于维持细胞的一些正常代谢功能，它受到了广泛关注。然而，超过140项在不同病理状况（如心肌梗死、胃炎、糖尿病、高血压、中风和癌症）下使用维生素C的临床试验结果并不一致。这种差异促使我们寻求新策略，以确定维生素C在心力衰竭甚至其预防中的实际意义。为了更好地理解维生素C的作用机制，重新审视其跨细胞膜转运和亚细胞相互作用非常重要。在本综述中，我们重点介绍了维生素C及其在心脏中的转运体的一些历史细节，特别关注癌症化疗中的心力衰竭。
