Schauersberger Jörg, Amon Michael, Aichinger Doris, Georgopoulos Apostoulos
Department of Ophthalmology, University Hospital of Vienna, Austria.
J Cataract Refract Surg. 2003 Feb;29(2):361-6. doi: 10.1016/s0886-3350(02)01741-8.
To determine the in vitro bacterial adherence to intraocular lenses (IOLs) routinely used at 1 center.
University Hospital of Vienna, Vienna, Austria.
Four types of rigid IOLs (hydrophobic poly[methyl methacrylate] [PMMA] and hydrophilic heparin-surface-modified PMMA) and 5 types of foldable intraocular lenses (hydrophobic silicone, hydrophobic acrylic, and hydrophilic acrylic) were used in the experiment. Under standardized conditions, the IOLs were contaminated with 2 strains of Staphylococcus epidermidis. A sonication method and impression method were used for quantification. The mean bacterial density per lens type (colony forming units/mm(2)) was compared.
With both germs and both quantification methods, more bacteria was found on hydrophobic lenses than on IOLs with hydrophilic surfaces (P =.001). The Alcon AcrySof and Askin UV80F IOLs had the greatest and the Corneal Acrygel and Bausch & Lomb Hydroview IOLs the least affinity to these microorganisms.
The data suggest that hydrophilic IOLs can help reduce the rate of postoperative endophthalmitis as a result of their surface properties.
确定某一中心常规使用的人工晶状体（IOL）的体外细菌黏附情况。
奥地利维也纳大学医院。
实验使用了4种硬性人工晶状体（疏水性聚甲基丙烯酸甲酯[PMMA]和亲水性肝素表面改性的PMMA）以及5种可折叠人工晶状体（疏水性硅酮、疏水性丙烯酸酯和亲水性丙烯酸酯）。在标准化条件下，人工晶状体被2株表皮葡萄球菌污染。采用超声处理法和印模法进行定量分析。比较每种人工晶状体类型的平均细菌密度（菌落形成单位/mm²）。
无论使用哪种细菌以及哪种定量方法，疏水性人工晶状体上发现的细菌都比具有亲水性表面的人工晶状体上的多（P = 0.001）。爱尔康AcrySof和Askin UV80F人工晶状体对这些微生物的亲和力最强，而角膜Acrygel和博士伦Hydroview人工晶状体的亲和力最弱。
数据表明，亲水性人工晶状体因其表面特性有助于降低术后眼内炎的发生率。
