Kinch Michael S, Carles-Kinch Kelly
MedImmune, Inc., Gaithersburg, Maryland 20878, USA.
Clin Exp Metastasis. 2003;20(1):59-68. doi: 10.1023/a:1022546620495.
Cancer is a disease of aberrant signal transduction. The expression and function of intracellular signaling pathways are frequently subverted as cells progress towards a metastatic phenotype. In particular, tyrosine kinases initiate powerful signals that govern many different aspects of cell behavior. In Recent studies have demonstrated that the EphA2 receptor tyrosine kinase is frequently overexpressed and functionally altered in aggressive tumor cells, and that these changes promote metastatic character. Herein, we provide an overview of our current understanding of EphA2, with emphasis upon the differential regulation of EphA2 expression and function. We also show that differential EphA2 expression and function may provide a unique opportunity for selective therapeutic targeting of EphA2 in metastatic disease.
癌症是一种信号转导异常的疾病。随着细胞向转移表型发展，细胞内信号通路的表达和功能常常被颠覆。特别是，酪氨酸激酶启动强大的信号，控制细胞行为的许多不同方面。最近的研究表明，EphA2受体酪氨酸激酶在侵袭性肿瘤细胞中经常过度表达且功能改变，并且这些变化促进转移特性。在此，我们概述了目前对EphA2的理解，重点是EphA2表达和功能的差异调节。我们还表明，EphA2表达和功能的差异可能为转移性疾病中EphA2的选择性治疗靶向提供独特的机会。
