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2
Increasing resistance of Streptococcus pneumoniae to fluoroquinolones: results of a Hong Kong multicentre study in 2000.肺炎链球菌对氟喹诺酮类药物的耐药性增加：2000年香港多中心研究结果
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J Antimicrob Chemother. 2003 Dec;52(6):944-52. doi: 10.1093/jac/dkg465. Epub 2003 Oct 29.
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Antimicrob Agents Chemother. 2007 Jun;51(6):2192-4. doi: 10.1128/AAC.00139-07. Epub 2007 Mar 19.
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Prevalence and molecular analysis of macrolide and fluoroquinolone resistance among isolates of Streptococcus pneumoniae collected during the 2000-2001 PROTEKT US Study.2000 - 2001年美国PROTEKT研究期间收集的肺炎链球菌分离株中大环内酯类和氟喹诺酮类耐药性的流行情况及分子分析
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Molecular epidemiology of multiresistant Streptococcus pneumoniae with both erm(B)- and mef(A)-mediated macrolide resistance.同时具有erm(B)和mef(A)介导的大环内酯类耐药性的多重耐药肺炎链球菌的分子流行病学
J Clin Microbiol. 2004 Feb;42(2):764-8. doi: 10.1128/JCM.42.2.764-768.2004.

本文引用的文献

1
Molecular characterization of macrolide resistance mechanisms among Streptococcus pneumoniae and Streptococcus pyogenes isolated from the PROTEKT 1999-2000 study.从1999 - 2000年PROTEKT研究中分离出的肺炎链球菌和化脓性链球菌大环内酯类耐药机制的分子特征
J Antimicrob Chemother. 2002 Sep;50 Suppl S1:39-47. doi: 10.1093/jac/dkf806.
2
Increasing prevalence of antimicrobial resistance among isolates of Streptococcus pneumoniae from the PROTEKT surveillance study, and compatative in vitro activity of the ketolide, telithromycin.来自PROTEKT监测研究的肺炎链球菌分离株中抗菌药物耐药性的患病率不断上升，以及酮内酯类药物泰利霉素的体外比较活性。
J Antimicrob Chemother. 2002 Sep;50 Suppl S1:25-37. doi: 10.1093/jac/dkf808.
3
Increasing resistance of Streptococcus pneumoniae to fluoroquinolones: results of a Hong Kong multicentre study in 2000.肺炎链球菌对氟喹诺酮类药物的耐药性增加：2000年香港多中心研究结果
J Antimicrob Chemother. 2001 Nov;48(5):659-65. doi: 10.1093/jac/48.5.659.
4
Nomenclature of major antimicrobial-resistant clones of Streptococcus pneumoniae defined by the pneumococcal molecular epidemiology network.由肺炎球菌分子流行病学网络定义的肺炎链球菌主要耐药克隆的命名法。
J Clin Microbiol. 2001 Jul;39(7):2565-71. doi: 10.1128/JCM.39.7.2565-2571.2001.
5
Target site modifications and efflux phenotype in clinical isolates of Streptococcus pneumoniae from Hong Kong with reduced susceptibility to fluoroquinolones.
J Antimicrob Chemother. 2001 May;47(5):655-8. doi: 10.1093/jac/47.5.655.
6
Worldwide prevalence of antimicrobial resistance in Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in the SENTRY Antimicrobial Surveillance Program, 1997-1999.1997 - 1999年哨兵抗菌监测项目中肺炎链球菌、流感嗜血杆菌和卡他莫拉菌的全球抗菌药物耐药性流行情况
Clin Infect Dis. 2001 May 15;32 Suppl 2:S81-93. doi: 10.1086/320181.
7
Resistance surveillance of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis isolated in Asia and Europe, 1997-1998.1997 - 1998年亚洲和欧洲分离出的肺炎链球菌、流感嗜血杆菌和卡他莫拉菌的耐药性监测
J Antimicrob Chemother. 2000 Apr;45(4):457-66. doi: 10.1093/jac/45.4.457.
8
The Alexander Project 1996-1997: latest susceptibility data from this international study of bacterial pathogens from community-acquired lower respiratory tract infections.1996 - 1997年亚历山大项目：这项关于社区获得性下呼吸道感染细菌病原体的国际研究的最新药敏数据。
J Antimicrob Chemother. 2000 Feb;45(2):191-203. doi: 10.1093/jac/45.2.191.
9
Macrolide resistance and erythromycin resistance determinants among Belgian Streptococcus pyogenes and Streptococcus pneumoniae isolates.比利时化脓性链球菌和肺炎链球菌分离株中的大环内酯耐药性及红霉素耐药决定因素
J Antimicrob Chemother. 2000 Feb;45(2):167-73. doi: 10.1093/jac/45.2.167.
10
Emergence of fluoroquinolone resistance among multiply resistant strains of Streptococcus pneumoniae in Hong Kong.香港多重耐药肺炎链球菌菌株中氟喹诺酮耐药性的出现。
Antimicrob Agents Chemother. 1999 May;43(5):1310-3. doi: 10.1128/AAC.43.5.1310.

香港耐氟喹诺酮或氟喹诺酮敏感肺炎链球菌的分子特征及抗菌药敏性

Molecular characterization and antimicrobial susceptibility of fluoroquinolone-resistant or -susceptible Streptococcus pneumoniae from Hong Kong.

作者信息

Morrissey Ian, Farrell David J, Bakker Sarah, Buckridge Sylvie, Felmingham David

机构信息

GR Micro Ltd., London, United Kingdom.

出版信息

Antimicrob Agents Chemother. 2003 Apr;47(4):1433-5. doi: 10.1128/AAC.47.4.1433-1435.2003.

DOI:10.1128/AAC.47.4.1433-1435.2003
PMID:12654686
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC152518/
Abstract

Fluoroquinolone resistance in Streptococcus pneumoniae isolated from Hong Kong as part of Prospective Resistant Organism Tracking and Epidemiology for the Ketolide Telithromycin 1999/2000 was found to be due to the spread of the Spain(23F)-1 clone (mainly a Spain(23F)-1-14 variant). All the isolates were multidrug resistant but were susceptible to quinupristin-dalfopristin, linezolid, and telithromycin. The Spain(23F)-1 clone also occurred among antimicrobial-susceptible isolates, which suggests that the primary source of this clone may have been Asia rather than Iberia.

摘要

作为1999/2000年酮内酯类泰利霉素前瞻性耐药菌追踪与流行病学研究的一部分，从香港分离出的肺炎链球菌对氟喹诺酮耐药，发现这是由于西班牙（23F）-1克隆株（主要是西班牙（23F）-1-14变体）的传播所致。所有分离株均对多种药物耐药，但对奎奴普丁-达福普汀、利奈唑胺和泰利霉素敏感。西班牙（23F）-1克隆株也出现在药敏试验敏感的分离株中，这表明该克隆株的主要来源可能是亚洲而非伊比利亚半岛。