经免疫的母鼠赋予受幽门螺杆菌攻击的新生小鼠的被动免疫可持续到断奶。
Passive immunity in Helicobacter-challenged neonatal mice conferred by immunized dams lasts until weaning.
作者信息
Corthésy-Theulaz Irène, Corthésy Blaise, Bachmann Daniel, Velin Dominique, Kraehenbuhl Jean-Pierre
机构信息
Division of Gastroenterology, Nestlé Research Center, CHUV Lausanne, CH-1000 Lausanne 26, Switzerland.
出版信息
Infect Immun. 2003 Apr;71(4):2226-9. doi: 10.1128/IAI.71.4.2226-2229.2003.
Abstract
The objective of this study was to examine the effect of breast-feeding by immunized dams on Helicobacter colonization in newborns. Urease-based immunization regimens failed to protect nursing pups against H. felis, whereas H. felis lysate-cholera toxin resulted in protection. This observation correlated with a high recognition of cell surface-expressed bacterial antigens by milk antibodies. Protection lasted until weaning, indicating that infection is maintained at undetectable levels by passive immunity but then resumes when breast-feeding stops.
摘要
本研究的目的是检测经免疫的母鼠进行母乳喂养对新生儿幽门螺杆菌定植的影响。基于脲酶的免疫方案未能保护哺乳幼崽免受猫幽门螺杆菌感染，而猫幽门螺杆菌裂解物-霍乱毒素则起到了保护作用。这一观察结果与乳汁抗体对细胞表面表达的细菌抗原的高度识别相关。保护作用持续到断奶，这表明被动免疫使感染维持在检测不到的水平，但在停止母乳喂养后感染又会复发。
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