van Lier H, Coenen A M L, Drinkenburg W H I M
Nijmegen Institute for Cognition and Information, Department of Biological Psychology, University of Nijmegen, 6500 HE Nijmegen, The Netherlands.
J Neurosci. 2003 Mar 15;23(6):2459-65. doi: 10.1523/JNEUROSCI.23-06-02459.2003.
A clear relationship exists between moment-to-moment behavioral elements and hippocampal rhythmical synchronous activity (RSA) (theta rhythm). However, behavioral elements are not isolated events but are part of behavioral sequences in a context of behavioral activity. By concurrently monitoring open field behavior and hippocampal EEG, EEG correlates of open field behavior in relation to preceding and following behavior were studied in Sprague Dawley rats to determine whether the behavioral context influences EEG correlates of behavior. Results show that preceding and subsequent behavioral patterns influenced the spectral power correlates of behavior. RSA power was increased when a "type 1 behavior" (voluntary movement) preceded the behavior compared with when a "type 2 behavior" (automatic movement, awake immobility) preceded it. The modulating effect of behavioral transitions was shown for several types of behaviors, and systematic modulation of hippocampal EEG correlates of behavior was demonstrated. The present report shows that the strong and systematic relationship between hippocampal RSA and behavior is modulated by the behavioral-sequential context. Thus, in addition to the well established relationship between RSA and motor activity, a second nonmotor process seems to contribute to hippocampal RSA. A likely candidate is a sensory process, which is in accordance with theories on the sensorimotor function of hippocampal RSA.
瞬间行为元素与海马节律性同步活动（RSA）（theta节律）之间存在明确的关系。然而，行为元素并非孤立事件，而是行为活动背景下行为序列的一部分。通过同时监测旷场行为和海马脑电图，在斯普拉格-道利大鼠中研究了旷场行为与前后行为相关的脑电图相关性，以确定行为背景是否会影响行为的脑电图相关性。结果表明，前后行为模式会影响行为的频谱功率相关性。与“2型行为”（自动运动、清醒不动）先于该行为时相比，当“1型行为”（自主运动）先于该行为时，RSA功率会增加。行为转变对多种行为类型都有调节作用，并且证明了行为的海马脑电图相关性存在系统性调节。本报告表明，海马RSA与行为之间强烈而系统的关系受到行为序列背景的调节。因此，除了RSA与运动活动之间已确立的关系外，第二个非运动过程似乎也对海马RSA有贡献。一个可能的候选因素是感觉过程，这与关于海马RSA感觉运动功能的理论相符。
