Vandentorren S, Baldi I, Annesi Maesano I, Charpin D, Neukirch F, Filleul L, Cantagrel A, Tessier J F
Laboratory of Occupational and Environmental Health, Victor Segalen Bordeaux 2 University, Bordeaux, France.
Eur Respir J. 2003 Mar;21(3):462-7. doi: 10.1183/09031936.03.00030303.
The Pollution Atmosphérique et Affections Respiratoires Chroniques (PAARC; Air Pollution and Chronic Respiratory Diseases) study provided the opportunity to examine the 25-yr mortality of 940 asthmatic adults drawn from a large population-based sample of 14,267 adults investigated during 1974-1976 in seven French cities. Vital statistics were collected in 2001 for the whole population. Multivariate survival analysis was used to assess exact survival rates in asthmatics and nonasthmatics taking relevant confounders into account. On average, the mortality rates obtained were 10.4 and 6.9 deaths 1,000 person-yrs-in asthmatics and nonasthmatics, respectively. On univariate analysis, asthma increased the relative risk (RR) of death by 1.48 (95% confidence interval (CI) 1.29-1.69). The association between asthma and death had an RR of 1.16 (95% CI 0.99-1.37) when age, sex, educational level, smoking habits, occupational exposure and forced expiratory volume in one second (FEV1) were taken into account. FEV1 was an important contributive factor causing increased risk of death in both smokers and nonsmokers. For instance, in asthmatics, the numbers of deaths due to respiratory disease and cancer appeared excessive. The present study suggests that asthmatics exhibit a higher risk of mortality.
大气污染与慢性呼吸道疾病（PAARC）研究提供了一个机会，可对从1974年至1976年期间在法国七个城市调查的14267名成年人的大型基于人群的样本中抽取的940名哮喘成年患者的25年死亡率进行研究。2001年收集了整个人口的生命统计数据。采用多变量生存分析来评估哮喘患者和非哮喘患者在考虑相关混杂因素后的精确生存率。平均而言，哮喘患者和非哮喘患者每1000人年的死亡率分别为10.4例和6.9例。单变量分析显示，哮喘使死亡相对风险（RR）增加了1.48（95%置信区间（CI）为1.29 - 1.69）。在考虑年龄、性别、教育水平、吸烟习惯、职业暴露和一秒用力呼气量（FEV1）后，哮喘与死亡之间的关联RR为1.16（95% CI为0.99 - 1.37）。FEV1是导致吸烟者和非吸烟者死亡风险增加的一个重要因素。例如，在哮喘患者中，呼吸系统疾病和癌症导致的死亡人数似乎过多。本研究表明哮喘患者表现出更高的死亡风险。
