Qu Yan-Liang, Liu Jun, Zhang Li-Xin, Wu Chun-Min, Chu Ai-Jie, Wen Bao-Lei, Ma Chao, Yan Xu-Yan, Zhang Xin, Wang De-Ming, Lv Xin, Hou Shu-Jian
Department of Anesthesiology, Hospital of PLA, Qingdao 266071, Shandong, China.
Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Oncotarget. 2017 Feb 14;8(7):11614-11620. doi: 10.18632/oncotarget.14595.
Some studies found that there was a significant association between asthma and the risk of lung cancer. However, the results are inconclusive. Therefore, we performed a meta-analysis. We searched the electronic databases for all relevant articles. Odds ratio (OR) with 95% confidence interval (CI) were used to calculate the strength of the association between asthma and lung cancer risk. Asthma was significantly associated with the increased risk of lung cancer (OR = 1.44; 95% CI 1.31-1.59; P < 0.00001; I2 = 83%). Additionally, asthma patients without smoking also had the increased lung cancer risk. In the subgroup analysis of race and gender, Caucasians, Asians, male, and female patients with asthma showed the increased risk of lung cancer. However, asthma was not significantly associated with lung adenocarcinoma risk. In the stratified analysis by asthma definition, significant associations were found between asthma and lung cancer in self-reported subgroup, questionnaire subgroup, and register databases subgroup. However, no significant association was observed in physician-diagnosed asthma subgroup. In conclusion, this meta-analysis suggested that asthma might be significantly associated with lung cancer risk.
一些研究发现，哮喘与肺癌风险之间存在显著关联。然而，结果尚无定论。因此，我们进行了一项荟萃分析。我们在电子数据库中检索了所有相关文章。采用比值比（OR）及95%置信区间（CI）来计算哮喘与肺癌风险之间关联的强度。哮喘与肺癌风险增加显著相关（OR = 1.44；95% CI 1.31 - 1.59；P < 0.00001；I2 = 83%）。此外，不吸烟的哮喘患者肺癌风险也增加。在种族和性别的亚组分析中，白种人、亚洲人、男性和女性哮喘患者的肺癌风险均增加。然而，哮喘与肺腺癌风险无显著关联。在按哮喘定义进行的分层分析中，自我报告亚组、问卷亚组和登记数据库亚组中哮喘与肺癌之间存在显著关联。然而，在医生诊断的哮喘亚组中未观察到显著关联。总之，这项荟萃分析表明，哮喘可能与肺癌风险显著相关。
