来自海洋海绵类星体属物种的新型炔酸。

New acetylenic acids from the marine sponge Stelletta species.

作者信息

Zhao Qingchun, Lee Seung-Yeon, Hong Jongki, Lee Chong-O, Im Kwang Sik, Sim Chung Ja, Lee Dong Seok, Jung Jee H

机构信息

College of Pharmacy, Pusan National University, Busan 609-735, Korea, Korea.

出版信息

J Nat Prod. 2003 Mar;66(3):408-11. doi: 10.1021/np020440z.

DOI:10.1021/np020440z

PMID:12662102

Abstract

Four new acetylenic acids were isolated from the marine sponge Stelletta sp. by bioactivity-guided fractionation. The planar structures were established on the basis of NMR and MS analysis. The stereochemistry was defined by combined use of CD spectroscopy and a chiral anisotropic reagent, phenylglycine methyl ester (PGME). The compounds were evaluated for cytotoxicity against a small panel of five human tumor cell lines and exhibited marginal to moderate cytotoxicity.

摘要

通过生物活性导向分离法从海洋海绵Stelletta sp.中分离出四种新的炔酸。基于核磁共振（NMR）和质谱（MS）分析确定了平面结构。通过圆二色光谱（CD）和手性各向异性试剂苯甘氨酸甲酯（PGME）联合使用确定了立体化学。对这些化合物针对一小部分五种人类肿瘤细胞系进行了细胞毒性评估，结果显示出轻微至中等程度的细胞毒性。